Synonyms: example 93 [WO2019114770A1] | SIAIS 164029
Compound class:
Synthetic organic
Comment: SIAIS164029 is a PROTAC type degrader of ALK tyrosine kinase proteins [1]. The tyrosine kinase inhibitor moiety of the molecule is an alectinib analogue ('Id' in the patent), and the CRBN-binding ligand is pomalidomide.
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Bioactivity Comments |
Inhibitory potency of SIAIS164029 at target kinases will be similar to that of the parent inhibitor 7739. It inibits proliferation of cells (that carry a NPM-ALK gene fusion and are highly sensitive to ALK inhibitors) with an IC50 of 27.3 nM [1]. |