Synonyms: example 93 [WO2019114770A1] | SIAIS 164029
Compound class:
Synthetic organic
Comment: SIAIS164029 is a PROTAC type degrader of ALK tyrosine kinase proteins [1]. The tyrosine kinase inhibitor moiety of the molecule is an alectinib analogue ('Id' in the patent), and the CRBN-binding ligand is pomalidomide.
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References |
1. Yang X, Jiang B, Song X, Lin H, Sun N, Chen J, Qiu X, Ren C, Kong Y. (2019)
Alk protein degradation agent and anti-tumor application thereof. Patent number: WO2019114770A1. Assignee: ShanghaiTech University. Priority date: 13/12/2017. Publication date: 20/06/2019. |