ChEMBL ligand: CHEMBL1107 (DL-WR-171669, Halofantrine)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHO cells	B	5.12	pKi	7500	nM	Ki	ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique	B	6.7	pIC50	199.53	nM	IC50	Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL	Inhibition of human Potassium channel HERG expressed in mammalian cells	B	6.7	pIC50	199.53	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL	Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state	F	6.7	pIC50	199.53	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831]
ChEMBL	Inhibition of human ERG in MCF7 cells	B	6.7	pIC50	199.53	nM	IC50	Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341]
ChEMBL	Inhibitory concentration against potassium channel HERG	B	6.7	pIC50	199.53	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL	K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1	F	6.71	pIC50	196	nM	IC50	J Med Chem (2002) 45: 3844-3853 [PMID:12190308]
ChEMBL	Inhibition of human ERG	B	6.71	pIC50	194.98	nM	IC50	Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibition of human ERG by fluorescence polarization assay	B	6.81	pIC50	156	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Inhibition of human cloned ERG	B	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
GtoPdb	-	-	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 1408-15 [PMID:19222165]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes	F	8.03	pIC50	9.3	nM	IC50	Bioorg Med Chem Lett (2001) 11: 423-424 [PMID:11212126]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay	F	8.05	pIC50	9	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	8.24	pIC50	5.8	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	8.55	pIC50	2.8	nM	IC50	Med Chem Res (2007) 16: 213-229

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]