ChEMBL ligand: CHEMBL515387 (Gosogliptin, Gosogliptina, Gosogliptine, PF-00734200, PF-734,200, PF-734200)
Amyloid-beta A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 3/Dipeptidyl peptidase III in Human [ChEMBL: CHEMBL4520] [GtoPdb: 2355] [UniProtKB: Q9NY33] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Rat [ChEMBL: CHEMBL4653] [GtoPdb: 1612] [UniProtKB: P14740] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] There should be some charts here, you may need to enable JavaScript!
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884] There should be some charts here, you may need to enable JavaScript!
prolyl endopeptidase/Prolyl endopeptidase in Human [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibition of APP in human leukocytes	B	4.52	pIC50	>30000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
ChEMBL	Inhibition of human recombinant DPP2	B	5.48	pIC50	3300	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
dipeptidyl peptidase 3/Dipeptidyl peptidase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4520] [GtoPdb: 2355] [UniProtKB: Q9NY33]
ChEMBL	Inhibition of DPP3 in human erythrocytes	B	4.52	pIC50	>30000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL	Inhibition of human recombinant DPP4	B	7.89	pIC50	12.9	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
ChEMBL	Inhibition of dipeptidyl peptidase 4 (unknown origin)	B	7.89	pIC50	12.9	nM	IC50	Med Chem Res (2013) 22: 4505-4521
ChEMBL	Inhibition of human plasma DPP4	B	7.95	pIC50	11.3	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4653] [GtoPdb: 1612] [UniProtKB: P14740]
ChEMBL	Inhibition of rat plasma DPP4	B	7.89	pIC50	12.8	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
ChEMBL	Inhibition of human DPP9	B	5.22	pIC50	5980	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
ChEMBL	Inhibition of human recombinant DPP8	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
ChEMBL	Inhibition of human FAP expressed in african green monkey COS1 cells	B	4.99	pIC50	10300	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]
prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
ChEMBL	Inhibition of POP	B	4.52	pIC50	>30000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1991-1995 [PMID:19275964]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]