ChEMBL ligand: CHEMBL483857 (2-((4-Phenoxyphenylsulfonyl)Methyl)Thiirane)
ADAM17 in Human [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] There should be some charts here, you may need to enable JavaScript!
MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] There should be some charts here, you may need to enable JavaScript!
MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] There should be some charts here, you may need to enable JavaScript!
MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] There should be some charts here, you may need to enable JavaScript!
MMP7/Matrix metalloproteinase 7 in Human [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] There should be some charts here, you may need to enable JavaScript!
MMP8/Matrix metalloproteinase 8 in Human [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] There should be some charts here, you may need to enable JavaScript!
MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL	Inhibition of TACE	B	5.43	pKi	3700	nM	Ki	Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL	Inhibition of human recombinant MMP14 catalytic domain by substrate hydrolysis based fluorescence spectrophotometry	B	6.96	pKi	110	nM	Ki	ACS Med Chem Lett (2011) 2: 177-181 [PMID:24900296]
ChEMBL	Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysis	B	7.43	pKi	37	nM	Ki	ACS Med Chem Lett (2012) 3: 490-495 [PMID:22737278]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL	Inhibition of recombinant human MMP2	B	7.55	pKi	28	nM	Ki	J Med Chem (2018) 61: 8825-8837 [PMID:30212201]
ChEMBL	Inhibition of MMP2	B	7.86	pKi	13.9	nM	Ki	Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL	Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometry	B	7.86	pKi	13.9	nM	Ki	ACS Med Chem Lett (2011) 2: 177-181 [PMID:24900296]
ChEMBL	Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysis	B	7.86	pKi	13.9	nM	Ki	ACS Med Chem Lett (2012) 3: 490-495 [PMID:22737278]
ChEMBL	Inhibition of recombinant human MMP2 expressed in human HeLaS3 cells using MOCAcPLGLA2pr(Dnp)-AR-NH2 as substrate incubated for 15 to 30 mins by fluorescence method	B	7.86	pKi	13.9	nM	Ki	J Med Chem (2020) 63: 10705-10725 [PMID:32459966]
GtoPdb	-	-	7.86	pKi	13.9	nM	Ki	J Am Chem Soc (2000) 122: 6799-6800
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL	Inhibition of MMP3	B	4.82	pKi	15000	nM	Ki	Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL	Inhibition of human recombinant MMP3 catalytic domain by substrate hydrolysis based fluorescence spectrophotometry	B	4.82	pKi	15000	nM	Ki	ACS Med Chem Lett (2011) 2: 177-181 [PMID:24900296]
ChEMBL	Competitive inhibition of human MMP3 using fluorogenic substrate by Dixon plot analysis	B	4.82	pKi	15000	nM	Ki	ACS Med Chem Lett (2012) 3: 490-495 [PMID:22737278]
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
ChEMBL	Inhibition of MMP7	B	4.02	pKi	96000	nM	Ki	Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL	Inhibition of human recombinant MMP7 catalytic domain by substrate hydrolysis based fluorescence spectrophotometry	B	4.02	pKi	96000	nM	Ki	ACS Med Chem Lett (2011) 2: 177-181 [PMID:24900296]
ChEMBL	Competitive inhibition of human MMP7 using fluorogenic substrate by Dixon plot analysis	B	4.02	pKi	96000	nM	Ki	ACS Med Chem Lett (2012) 3: 490-495 [PMID:22737278]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL	Non-competitive inhibition of MMP8 (unknown origin)	B	5.68	pKi	2100	nM	Ki	J Med Chem (2018) 61: 8825-8837 [PMID:30212201]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
GtoPdb	-	-	6.22	pKi	600	nM	Ki	J Am Chem Soc (2000) 122: 6799-6800
ChEMBL	Inhibition of MMP9	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL	Inhibition of human recombinant MMP9 catalytic domain by substrate hydrolysis based fluorescence spectrophotometry	B	6.22	pKi	600	nM	Ki	ACS Med Chem Lett (2011) 2: 177-181 [PMID:24900296]
ChEMBL	Competitive inhibition of human MMP9 using fluorogenic substrate by Dixon plot analysis	B	6.22	pKi	600	nM	Ki	ACS Med Chem Lett (2012) 3: 490-495 [PMID:22737278]
ChEMBL	Inhibition of recombinant human MMP9 expressed in human HeLaS3 cells using MOCAcPLGLA2pr(Dnp)-AR-NH2 as substrate incubated for 15 to 30 mins by fluorescence method	B	6.22	pKi	600	nM	Ki	J Med Chem (2020) 63: 10705-10725 [PMID:32459966]
ChEMBL	Inhibition of recombinant human MMP9	B	6.4	pKi	400	nM	Ki	J Med Chem (2018) 61: 8825-8837 [PMID:30212201]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]