tozadenant [Ligand Id: 5611] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2105747 (A-2A (3), A2A (3), A2A-(3), RO4494351, RO-4494351, RO-4494351000, RO-4494351-000, RO4494351-000, RO-4494351-002, RO4494351-002, SYN115, SYN-115, Tozadenant)
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
  • A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
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  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Displacement of [3H]-DPCPX from recombinant human A1 receptor expressed in CHO-K1 cells incubated for 70 mins by liquid scintillation counting method B 5.47 pKi 3380 nM Ki Eur J Med Chem (2021) 214: 113214-113214 [PMID:33548636]
ChEMBL Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes incubated for 90 mins by radioligand competition assay B 5.65 pKi 2240 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
ChEMBL Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes measured after 90 mins B 5.77 pKi 1700 nM Ki J Med Chem (2017) 60: 681-694 [PMID:28055204]
ChEMBL Inhibition of human recombinant adenosine A1 receptor B 5.87 pKi 1350 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL Inhibition of human adenosine A1 receptor B 5.87 pKi 1350 nM Ki J Med Chem (2020) 63: 12196-12212 [PMID:32667814]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membranes measured after 90 mins B 7.96 pKi 11 nM Ki J Med Chem (2017) 60: 681-694 [PMID:28055204]
ChEMBL Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assay B 8.08 pKi 8.3 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
GtoPdb - - 8.3 pKi 5 nM Ki J Med Chem (2014) 57: 3623-50 [PMID:24164628]
ChEMBL Inhibition of human recombinant adenosine receptor A2a F 8.3 pKi 5 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL Antagonist activity at human adenosine 2A receptor (409 to 412 residues) expressed in CHO cells using Ysi-poly-1-lysine as substrate incubated for 1 hr in presence of 3H-SCH-58261 by scintillation counting method B 8.3 pKi 5 nM Ki J Med Chem (2020) 63: 12196-12212 [PMID:32667814]
ChEMBL Displacement of [3H]-ZM241385 from recombinant human A2A receptor expressed in CHO-K1 cells incubated for 70 mins by liquid scintillation counting method B 8.41 pKi 3.9 nM Ki Eur J Med Chem (2021) 214: 113214-113214 [PMID:33548636]
ChEMBL Antagonist activity at human adenosine A2A receptor expressed in HEK293 cell membranes assessed as decrease in CGS-21680/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 30 mins and subsequent forskolin stimulation measured after 30 mins F 9.52 pKi 0.3 nM Ki J Med Chem (2017) 60: 681-694 [PMID:28055204]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL Displacement of [3H]-ZM241385 from A2A receptor in rat brain corpora striata incubated for 70 mins by liquid scintillation counting method B 7.73 pKi 18.7 nM Ki Eur J Med Chem (2021) 214: 113214-113214 [PMID:33548636]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins B 5.3 pKi 5000 nM Ki J Med Chem (2017) 60: 681-694 [PMID:28055204]
ChEMBL Inhibition of human recombinant adenosine receptor A2b B 6.15 pKi 700 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL Inhibition of human adenosine 2B receptor B 6.15 pKi 700 nM Ki J Med Chem (2020) 63: 12196-12212 [PMID:32667814]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Displacement of [3H]-HEMADO from human adenosine A3 receptor expressed in HEK293 cell membranes measured after 90 mins B 5.3 pKi 5000 nM Ki J Med Chem (2017) 60: 681-694 [PMID:28055204]
ChEMBL Inhibition of human recombinant adenosine A3 receptor B 5.8 pKi 1570 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]