Synonyms: STX721
Compound class:
Synthetic organic
Comment: STX-721 is an oral, covalent and 'wild-type-sparing' EGFR inhibitor with selectivity for ex20ins (exon 20 insertion) mutatant receptors which are associated with resistance to commonly used EGFR inhibitors such as gefitinib and erlotinib. Targeting the mutated receptor is predicted to reduce skin and gut toxicities that are associated with wild-type EGFR inhibition. This chemical structure was obtained via Drug Hunter, as one of the 'first disclosure' novel small molecules revealed at the ACS meeting in August 2023.
|
|
Classification | |
Compound class | Synthetic organic |
IUPAC Name |
3-(3-chloro-2-methoxyanilino)-2-[3-[2-[(2R)-1-[(E)-4-(dimethylamino)but-2-enoyl]-2-methylpyrrolidin-2-yl]ethynyl]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one |
Synonyms |
STX721 |
Database Links | |
GtoPdb PubChem SID | 485206125 |
PubChem CID | 163224105 |
Search Google for chemical match using the InChIKey | UMSJPISUMQOUKS-LMZGTLAXSA-N |
Search Google for chemicals with the same backbone | UMSJPISUMQOUKS |
UniChem Compound Search for chemical match using the InChIKey | UMSJPISUMQOUKS-LMZGTLAXSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | UMSJPISUMQOUKS-LMZGTLAXSA-N |