Synonyms: STX721
Compound class:
Synthetic organic
Comment: STX-721 is an oral, covalent and 'wild-type-sparing' EGFR inhibitor with selectivity for ex20ins (exon 20 insertion) mutatant receptors which are associated with resistance to commonly used EGFR inhibitors such as gefitinib and erlotinib. Targeting the mutated receptor is predicted to reduce skin and gut toxicities that are associated with wild-type EGFR inhibition. This chemical structure was obtained via Drug Hunter, as one of the 'first disclosure' novel small molecules revealed at the ACS meeting in August 2023.
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No information available. |
Summary of Clinical Use |
STX-721 is a clinical candidate for the treatment of EGFR ex20ins +ve NSCLC. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT06043817 | First-In-Human Study of STX-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations | Phase 1/Phase 2 Interventional | Scorpion Therapeutics, Inc. |