aclidinium [Ligand Id: 7449] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1194325 (Aclidinium)
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
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  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL [3H]-NMS Binding Assay: The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25° C. Membrane preparations from stably transfected chinese hamster ovary-K1 cells (CHO) expressing the genes for the human muscarinic receptors Hm3 were used. B 8.36 pIC50 4.4 nM IC50 US-9333195-B2. Quinuclidine derivatives and medicinal compositions containing the same (2016)
GtoPdb - - 9.77 pIC50 0.17 nM IC50 J. Med. Chem. (2009) 52: 5076-92 [PMID:19653626]
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb Human M1 receptors expressed in CHO-K1 cells - 9.85 pIC50 0.14 nM IC50 J. Med. Chem. (2009) 52: 5076-92 [PMID:19653626]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 9.77 pIC50 0.17 nM IC50 J. Med. Chem. (2009) 52: 5076-92 [PMID:19653626]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]