aclidinium [Ligand Id: 7449] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1194325 (Aclidinium, Aclidinium cation, Aclidinium ion) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| GtoPdb | - | - | 10.2 | pKi | - | - | - |
J Med Chem (2009) 52: 5076-92 [PMID:19653626]; Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042] |
| ChEMBL | [3H]-NMS Binding Assay: The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25° C. Membrane preparations from stably transfected chinese hamster ovary-K1 cells (CHO) expressing the genes for the human muscarinic receptors Hm3 were used. | B | 8.36 | pIC50 | 4.4 | nM | IC50 | US-9333195-B2. Quinuclidine derivatives and medicinal compositions containing the same (2016) |
| M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| GtoPdb | - | - | 10.2 | pIC50 | - | - | IC50 |
J Med Chem (2009) 52: 5076-92 [PMID:19653626]; Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042] |
| M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| GtoPdb | - | - | 10.1 | pIC50 | - | - | IC50 |
J Med Chem (2009) 52: 5076-92 [PMID:19653626]; Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042] |
| M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| GtoPdb | - | - | 10 | pKi | - | - | - | Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042] |
| M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| GtoPdb | - | - | 9.9 | pKi | - | - | - | Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
