aclidinium [Ligand Id: 7449] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1194325 (Aclidinium)
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • This target only has 1 pki data point
  • 10.2
1 CHEMBL1194325_lig_chart_1 Muscarinic acetylcholine receptor M3 Human
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  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1194325_lig_chart_2 M1 receptor Human
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
  • This target only has 0 pki data point
  • 0
3 CHEMBL1194325_lig_chart_3 M2 receptor Human
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
  • This target only has 1 pki data point
  • 10
4 CHEMBL1194325_lig_chart_4 M4 receptor Human
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  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
  • This target only has 1 pki data point
  • 9.9
5 CHEMBL1194325_lig_chart_5 M5 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 10.2 pKi - - - J Med Chem (2009) 52: 5076-92 [PMID:19653626];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
ChEMBL [3H]-NMS Binding Assay: The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25° C. Membrane preparations from stably transfected chinese hamster ovary-K1 cells (CHO) expressing the genes for the human muscarinic receptors Hm3 were used. B 8.36 pIC50 4.4 nM IC50 US-9333195-B2. Quinuclidine derivatives and medicinal compositions containing the same (2016)
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 10.2 pIC50 - - IC50 J Med Chem (2009) 52: 5076-92 [PMID:19653626];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 10.1 pIC50 - - IC50 J Med Chem (2009) 52: 5076-92 [PMID:19653626];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 10 pKi - - - Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 9.9 pKi - - - Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]