PSAB-OFP [Ligand Id: 3968] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL195345
  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitine B 8.51 pKi 3.1 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4727-4730 [PMID:16165358]
ChEMBL Binding affinity to human alpha7 nAChR B 8.7 pKi 2 nM Ki Bioorg Med Chem Lett (2017) 27: 5002-5005 [PMID:29050783]
GtoPdb - - 5.7 pEC50 2200 nM EC50 Eur. J. Pharmacol. (2002) 452: 137-44 [PMID:12354563]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377374373376375] [UniProtKB: A5X5Y0O95264P46098Q70Z44Q8WXA8]
ChEMBL Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630 B 7.14 pKi 73 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4727-4730 [PMID:16165358]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Binding affinity to 5-HT3A receptor (unknown origin) B 8.7 pKi 2 nM Ki Bioorg Med Chem Lett (2017) 27: 5002-5005 [PMID:29050783]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]