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ChEMBL ligand: CHEMBL1643208 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
ChEMBL | Inhibition of recombinant CDK2/Cyclin A expressed in insect Sf9 cells assessed as inhibition of [33P]-ATP incorporation into biotinylated histone H1 after 1 hr by liquid scintillation counting | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg. Med. Chem. Lett. (2011) 21: 471-474 [PMID:21094607] |
GtoPdb | CDK2/cyclin A complex in assay | - | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 471-4 [PMID:21094607] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 471-4 [PMID:21094607] |
ChEMBL | Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assay | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg. Med. Chem. Lett. (2011) 21: 471-474 [PMID:21094607] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]