sildenafil [Ligand Id: 4743] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL192 (HIP-0908, Revatio, UK-92480, Vizarsin, Sildenafil, HIP0908, Nipatra, Viagra)
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
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  • indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase 1 in Mouse [ChEMBL: CHEMBL1075294] [GtoPdb: 2829] [UniProtKB: P28776]
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  • indoleamine 2,3-dioxygenase 2/Indoleamine 2,3-dioxygenase 2 in Mouse [ChEMBL: CHEMBL2189159] [GtoPdb: 3019] [UniProtKB: Q8R0V5]
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  • ABCC4/Multidrug resistance-associated protein 4 in Human [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439]
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  • ABCC5/Multidrug resistance-associated protein 5 in Human [ChEMBL: CHEMBL2046258] [GtoPdb: 783] [UniProtKB: O15440]
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  • phosphodiesterase 10A/Phosphodiesterase 10A in Human [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
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  • phosphodiesterase 11A/Phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
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  • phosphodiesterase 1A/Phosphodiesterase 1A in Human [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
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  • phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
  • Phosphodiesterase 2A in Bovine [ChEMBL: CHEMBL3477] [UniProtKB: P14099]
  • phosphodiesterase 2A/Phosphodiesterase 2A in Rat [ChEMBL: CHEMBL4650] [GtoPdb: 1297] [UniProtKB: Q01062]
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  • phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
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  • phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
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  • phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
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  • phosphodiesterase 6C/Phosphodiesterase 6C in Human [ChEMBL: CHEMBL3977] [GtoPdb: 1314] [UniProtKB: P51160]
  • Phosphodiesterase 6C in Bovine [ChEMBL: CHEMBL3479] [UniProtKB: P16586]
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  • phosphodiesterase 7A/Phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
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  • phosphodiesterase 8A/Phosphodiesterase 8A in Human [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
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  • phosphodiesterase 9A/Phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
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  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
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  • OATP1B3 in Human [GtoPdb: 1221] [UniProtKB: Q9NPD5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) B 6.06 pKi 871 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) B 5.83 pIC50 1493 nM IC50 DrugMatrix in vitro pharmacology data
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Displacement of [3H]ZM241385 from human AA2AR expressed in HEK293T cells after 2 hrs by liquid scintillation counter B 6.7 pKi 199.53 nM Ki J. Med. Chem. (2012) 55: 5311-5325 [PMID:22563707]
ChEMBL DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) B 6.85 pKi 142 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) B 6.6 pIC50 253 nM IC50 DrugMatrix in vitro pharmacology data
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) B 6.09 pKi 806 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) B 5.84 pIC50 1457 nM IC50 DrugMatrix in vitro pharmacology data
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG in MCF7 cells B 4 pIC50 100000 nM IC50 Eur. J. Med. Chem. (2009) 44: 1926-1932 [PMID:19110341]
ChEMBL K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 F 4 pIC50 100000 nM IC50 J. Med. Chem. (2002) 45: 3844-3853 [PMID:12190308]
ChEMBL Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform F 4 pIC50 100000 nM IC50 J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
ChEMBL Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay F 4.5 pIC50 31622.78 nM IC50 J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique B 5.48 pIC50 3311.31 nM IC50 Bioorg. Med. Chem. (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL Inhibition of human ERG B 5.48 pIC50 3311.31 nM IC50 Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
ChEMBL Inhibitory concentration against potassium channel HERG B 5.48 pIC50 3311.31 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL Inhibition of human Potassium channel HERG expressed in mammalian cells B 5.48 pIC50 3311.31 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL Inhibition of human ERG channel B 5.48 pIC50 3300 nM IC50 J. Med. Chem. (2009) 52: 4266-4276 [PMID:19534531]
ChEMBL Inhibition of human ERG channel B 5.48 pIC50 3300 nM IC50 J. Med. Chem. (2009) 52: 4266-4276 [PMID:19534531]
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075294] [GtoPdb: 2829] [UniProtKB: P28776]
ChEMBL Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7641-7646 [PMID:23122865]
indoleamine 2,3-dioxygenase 2/Indoleamine 2,3-dioxygenase 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189159] [GtoPdb: 3019] [UniProtKB: Q8R0V5]
ChEMBL Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis B 5.35 pIC50 4500 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7641-7646 [PMID:23122865]
ABCC4/Multidrug resistance-associated protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439]
ChEMBL TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP4-expressing HEK293 cells F 4.7 pIC50 20000 nM IC50 Mol. Pharmacol. (2003) 63: 1094-1103 [PMID:12695538]
ABCC5/Multidrug resistance-associated protein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046258] [GtoPdb: 783] [UniProtKB: O15440]
GtoPdb - - 5.92 pKi 1200 nM Ki J. Med. Chem. (2012) 55: 3049-57 [PMID:22380603]
ChEMBL Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scintillation counting B 5.92 pKi 1200 nM Ki J. Med. Chem. (2012) 55: 3049-3057 [PMID:22380603]
ChEMBL TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP5-expressing HEK293 cells F 4.1 pIC50 80000 nM IC50 Mol. Pharmacol. (2003) 63: 1094-1103 [PMID:12695538]
phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
ChEMBL Inhibition of human recombinant PDE10A2 at 1 uM by [3H]cGMP based tritium scintillation proximity assay B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2012) 55: 10540-10550 [PMID:23137303]
ChEMBL Inhibition of PDE10 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assay B 5.17 pIC50 6800 nM IC50 Eur. J. Med. Chem. (2013) 60: 285-294 [PMID:23313637]
ChEMBL Inhibition of PDE10A1 (unknown origin) using fluorescently labeled cAMP substrate by fluorescence polarization assay B 5.27 pIC50 5400 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
ChEMBL Inhibitory concentration against human phosphodiesterase 10 B 5.51 pIC50 3100 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2365-2369 [PMID:15837326]
phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL Inhibition of GST-tagged recombinant human PDE11A4 B 5.11 pIC50 7800 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
ChEMBL Inhibition of PDE11 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assay B 5.21 pIC50 6100 nM IC50 Eur. J. Med. Chem. (2013) 60: 285-294 [PMID:23313637]
ChEMBL Inhibition of human recombinant PDE11A4 at 1 uM by [3H]cGMP based tritium scintillation proximity assay B 5.38 pIC50 4210 nM IC50 J. Med. Chem. (2012) 55: 10540-10550 [PMID:23137303]
ChEMBL Inhibition of human recombinant PDE11 B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6279-6282 [PMID:18976905]
ChEMBL Inhibition of human recombinant PDE11 B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 383-386 [PMID:19906530]
ChEMBL Inhibition of human phosphodiesterase 11 B 5.64 pIC50 2300 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2365-2369 [PMID:15837326]
phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
ChEMBL Inhibition of PDE1A1 (unknown origin) using fluorescently labeled cAMP substrate by fluorescence polarization assay B 6.22 pIC50 600 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL Inhibition of PDE2A1 (unknown origin) using fluorescently labeled cAMP substrate by fluorescence polarization assay B 4.2 pIC50 63000 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
ChEMBL Inhibition of Human recombinant PDE2 (Phosphodiesterase 2) B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2003) 46: 4533-4542 [PMID:14521415]
ChEMBL Inhibition of human recombinant PDE2 (phosphodiesterase 2) B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2003) 46: 4525-4532 [PMID:14521414]
ChEMBL Inhibition of Phosphodiesterase 2 B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1829-1833 [PMID:15780616]
ChEMBL Inhibition of human phosphodiesterase 2 B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2365-2369 [PMID:15837326]
ChEMBL Inhibition of PDE2 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assay B 5 pIC50 >10000 nM IC50 Eur. J. Med. Chem. (2013) 60: 285-294 [PMID:23313637]
Phosphodiesterase 2A in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3477] [UniProtKB: P14099]
ChEMBL Inhibitory activity against phosphodiesterase-2 (PDE2) isolated from bovine adrenal gland B 4.37 pIC50 43000 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2341-2345 [PMID:12824030]
ChEMBL Inhibition of bovine adrenal gland Phosphodiesterase 2 (PDE2) B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2001) 44: 2204-2218 [PMID:11405657]
phosphodiesterase 2A/Phosphodiesterase 2A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4650] [GtoPdb: 1297] [UniProtKB: Q01062]
ChEMBL Inhibitory concentration against phosphodiesterase 2 from rat kidney B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 2955-2958 [PMID:15125967]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL Inhibition of PDE3A (unknown origin) using fluorescently labeled cAMP substrate by fluorescence polarization assay B 4.59 pIC50 26000 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
Phosphodiesterase 3B in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5129] [UniProtKB: E1BN64]
ChEMBL Inhibition of bovine aorta PDE3 (Phosphodiesterase 3) B 5.04 pIC50 9200 nM IC50 J. Med. Chem. (2003) 46: 4533-4542 [PMID:14521415]
ChEMBL Inhibition of bovine aorta PDE3 (phosphodiesterase 3) B 5.04 pIC50 9200 nM IC50 J. Med. Chem. (2003) 46: 4525-4532 [PMID:14521414]
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL Inhibition of PDE4A1 (unknown origin) using fluorescently labeled cAMP substrate by fluorescence polarization assay B 5.3 pIC50 5000 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL Inhibition of human PDE4D B 4.7 pIC50 20000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2204-2218 [PMID:20188577]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL Inhibition of human phosphodiesterase 5 B 8 pKi 10 nM Ki J. Med. Chem. (2005) 48: 3449-3462 [PMID:15887951]
ChEMBL Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluated B 8.72 pKi 1.91 nM Ki J. Med. Chem. (2003) 46: 441-444 [PMID:12540243]
ChEMBL Inhibitory activity against human Phosphodiesterase 5 B 8.72 pKi 1.91 nM Ki J. Med. Chem. (2004) 47: 656-662 [PMID:14736245]
ChEMBL Phosphodiesterase 5 activity of human corpus cavernosum B 8.73 pKi 1.87 nM Ki J. Med. Chem. (2002) 45: 4094-4096 [PMID:12213052]
ChEMBL Inhibitory activity against PDE5 from human corpus cavernosum B 8.73 pKi 1.87 nM Ki Bioorg. Med. Chem. Lett. (2003) 13: 761-765 [PMID:12639576]
ChEMBL Inhibition of PDE5 (unknown origin) B 8.8 pKi 1.6 nM Ki Eur J Med Chem (2018) 158: 767-780 [PMID:30245400]
ChEMBL Inhibition of human PDE5A preincubated for 30 mins followed by TMB substrate addition by spectrophotometry B 4.9 pIC50 12590 nM IC50 Bioorg Med Chem Lett (2017) 27: 4180-4184 [PMID:28751142]
ChEMBL Inhibition of human recombinant PDE5A1 expressed in COS7 cells B 7.12 pIC50 75 nM IC50 J. Nat. Prod. (2008) 71: 1513-1517 [PMID:18778098]
ChEMBL Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis B 7.28 pIC50 53 nM IC50 J. Med. Chem. (2008) 51: 2807-2815 [PMID:18393409]
ChEMBL Inhibition of human Phosphodiesterase 5 (n=2-3) B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2381-2384 [PMID:15837329]
ChEMBL Inhibition of PDE5 B 7.7 pIC50 20 nM IC50 J. Med. Chem. (2006) 49: 5363-5371 [PMID:16913726]
ChEMBL Inhibitory concentration against phosphodiesterase 5 (PDE5) from human platelet B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 2955-2958 [PMID:15125967]
ChEMBL Inhibition of PDE5A (unknown origin) B 8.07 pIC50 8.5 nM IC50 Eur J Med Chem (2018) 150: 506-524 [PMID:29549837]
ChEMBL Inhibition of recombinant human PDE5A B 8.07 pIC50 8.5 nM IC50 J Med Chem (2016) 59: 8967-9004 [PMID:27606546]
ChEMBL Inhibition of PDE5 B 8.18 pIC50 6.61 nM IC50 Bioorg. Med. Chem. (2008) 16: 7599-7606 [PMID:18656371]
ChEMBL Inhibition of Phosphodiesterase 5 B 8.18 pIC50 6.6 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 865-868 [PMID:11958981]
ChEMBL Inhibition of phosphodiesterase 5 B 8.18 pIC50 6.6 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3900-3907 [PMID:15993055]
ChEMBL Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assay B 8.25 pIC50 5.6 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
ChEMBL Inhibition of PDE5A1 (unknown origin) B 8.25 pIC50 5.6 nM IC50 Bioorg. Med. Chem. (2015) 23: 2121-2128 [PMID:25801159]
ChEMBL Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liquid scintillation counting B 8.29 pIC50 5.1 nM IC50 J Med Chem (2018) 61: 8468-8473 [PMID:30148362]
ChEMBL DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) B 8.34 pIC50 4.58 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of full length recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected Sf9 cells using cGMP as substrate after 30 mins by HTRF assay B 8.4 pIC50 4 nM IC50 J Med Chem (2016) 59: 8967-9004 [PMID:27606546]
ChEMBL Inhibition of PDE5 (unknown origin) B 8.4 pIC50 3.98 nM IC50 J Med Chem (2018) 61: 6421-6467 [PMID:29620890]
ChEMBL Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay B 8.41 pIC50 3.9 nM IC50 J. Med. Chem. (2012) 55: 10540-10550 [PMID:23137303]
ChEMBL Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain expressed in Baculovirus infected Sf9 insect cells using FAM-cGMP as substrate after 1 hr by fluorescence polarization assay B 8.44 pIC50 3.65 nM IC50 Eur J Med Chem (2018) 150: 30-38 [PMID:29505934]
ChEMBL Inhibition of PDE5 B 8.44 pIC50 3.63 nM IC50 Bioorg. Med. Chem. (2008) 16: 7599-7606 [PMID:18656371]
ChEMBL Inhibition of Phosphodiesterase 5 from rabbit platelets B 8.44 pIC50 3.6 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 1819-1824
ChEMBL Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determined B 8.46 pIC50 3.5 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 3149-3152 [PMID:12372521]
ChEMBL Inhibition of human corpus cavernosum PDE5 B 8.46 pIC50 3.5 nM IC50 J. Med. Chem. (2006) 49: 3581-3594 [PMID:16759100]
ChEMBL Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay B 8.46 pIC50 3.5 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6033-6036 [PMID:18951784]
ChEMBL Inhibition of PDE5 B 8.46 pIC50 3.5 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3125-3128 [PMID:20400309]
ChEMBL Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzyme B 8.46 pIC50 3.5 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 1291-1294 [PMID:14980684]
ChEMBL Inhibition of human phosphodiesterase 5 B 8.46 pIC50 3.5 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2365-2369 [PMID:15837326]
ChEMBL Inhibition of phosphodiesterase 5 isolated from human platelets B 8.52 pIC50 3 nM IC50