OSI-930 [Ligand Id: 9383] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1614710 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| GtoPdb | The IC50 varied dependent on whether KIT was activated or unactivated, with the lower value measured for the activated enzyme. | - | 7.6 | pIC50 | 25 | nM | IC50 | Cancer Res (2006) 66: 1015-24 [PMID:16424037] |
| colony stimulating factor 1 receptor in Human [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | Cancer Res (2006) 66: 1015-24 [PMID:16424037] |
| fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | Cancer Res (2006) 66: 1015-24 [PMID:16424037] |
| kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | - | - | 8.05 | pIC50 | 9 | nM | IC50 | Cancer Res (2006) 66: 1015-24 [PMID:16424037] |
| Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| GtoPdb | - | - | 7.39 | pIC50 | 41 | nM | IC50 | Cancer Res (2006) 66: 1015-24 [PMID:16424037] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
