eprosartan   Click here for help

GtoPdb Ligand ID: 588

Synonyms: Eprozar® | SK-108566 | Teveten®
Approved drug
eprosartan is an approved drug (FDA (1997))
Compound class: Synthetic organic
Comment: Eprosartan is an antagonist of the type 1 angiotensin II receptor (AGTR1).
Marketed formulations may contain eprosartan mesylate (PubChem CID 5282474).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 120.66
Molecular weight 424.15
XLogP 3.89
No. Lipinski's rules broken 0
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Canonical SMILES CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)C=C(C(=O)O)Cc1cccs1
Isomeric SMILES CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1
InChI InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1997))
IUPAC Name Click here for help
4-[[2-butyl-5-[(E)-3-hydroxy-3-oxo-2-(thiophen-2-ylmethyl)prop-1-enyl]imidazol-1-yl]methyl]benzoic acid
International Nonproprietary Names Click here for help
INN number INN
7223 eprosartan
Synonyms Click here for help
Eprozar® | SK-108566 | Teveten®
Database Links Click here for help
Specialist databases
GPCRdb Ligand eprosartan
Reactome Drug Reactome logo R-ALL-9615301
Reactome Reaction Reactome logo R-HSA-9615249
Other databases
CAS Registry No. 133040-01-4 (source: Scifinder)
DrugBank Ligand DB00876
DrugCentral Ligand 1037
GtoPdb PubChem SID 135650236
PubChem CID 5281037
Search Google for chemical match using the InChIKey OROAFUQRIXKEMV-LDADJPATSA-N
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UniChem Compound Search for chemical match using the InChIKey OROAFUQRIXKEMV-LDADJPATSA-N
UniChem Connectivity Search for chemical match using the InChIKey OROAFUQRIXKEMV-LDADJPATSA-N
Wikipedia Eprosartan