eprosartan   Click here for help

GtoPdb Ligand ID: 588

Synonyms: Eprozar® | SK-108566 | Teveten®
Approved drug
eprosartan is an approved drug (FDA (1997))
Compound class: Synthetic organic
Comment: Eprosartan is an antagonist of the type 1 angiotensin II receptor (AGTR1).
Marketed formulations may contain eprosartan mesylate (PubChem CID 5282474).
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: eprosartan

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 120.66
Molecular weight 424.15
XLogP 3.89
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)C=C(C(=O)O)Cc1cccs1
Isomeric SMILES CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1
InChI InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
AT1 receptor Primary target of this compound Hs Antagonist Antagonist 8.4 – 8.8 pIC50 - 1
pIC50 8.4 – 8.8 (IC50 3.98x10-9 – 1.58x10-9 M) [1]