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ChEMBL ligand: CHEMBL179583 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
GtoPdb | - | - | 7.43 | pKi | 37 | nM | Ki | Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363] |
ChEMBL | Inhibition of Chk2 | B | 7.43 | pKi | 37 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of recombinant human Chk2 kinase | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2005) 48: 1873-1885 [PMID:15771432] |
ChEMBL | Inhibition of chk2 kinase | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1924-1928 [PMID:16442290] |
ChEMBL | Inhibition of recombinant human CDS1 using N-terminal biotin-labeled SGLYRSPSMPENLNRPR as substrate in presence of [gamma-33P]-ADP after 3 hrs by scintillation counting method | B | 7.8 | pIC50 | 16 | nM | IC50 | EP-1435947-B1. 2-phenyl benzimidazoles and imidazo-4,5|-pyridines as CDS1/CHK2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer (2007) |
ChEMBL | Inhibition of recombinant human Chk2 kinase | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2005) 48: 1873-1885 [PMID:15771432] |
ChEMBL | Inhibition of human recombinant Chk2 | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6467-6471 [PMID:17937984] |
ChEMBL | Inhibition of Chk2 | B | 7.82 | pIC50 | 15 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]