Chk2 inhibitor II [Ligand Id: 5954] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL179583
  • checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
GtoPdb - - 7.43 pKi 37 nM Ki Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]
ChEMBL Inhibition of Chk2 B 7.43 pKi 37 nM Ki Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of recombinant human Chk2 kinase B 7.8 pIC50 16 nM IC50 J Med Chem (2005) 48: 1873-1885 [PMID:15771432]
ChEMBL Inhibition of chk2 kinase B 7.8 pIC50 16 nM IC50 Bioorg Med Chem Lett (2006) 16: 1924-1928 [PMID:16442290]
ChEMBL Inhibition of recombinant human CDS1 using N-terminal biotin-labeled SGLYRSPSMPENLNRPR as substrate in presence of [gamma-33P]-ADP after 3 hrs by scintillation counting method B 7.8 pIC50 16 nM IC50 EP-1435947-B1. 2-phenyl benzimidazoles and imidazo-4,5|-pyridines as CDS1/CHK2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer (2007)
ChEMBL Inhibition of recombinant human Chk2 kinase B 7.82 pIC50 15 nM IC50 J Med Chem (2005) 48: 1873-1885 [PMID:15771432]
ChEMBL Inhibition of human recombinant Chk2 B 7.82 pIC50 15 nM IC50 Bioorg Med Chem Lett (2007) 17: 6467-6471 [PMID:17937984]
ChEMBL Inhibition of Chk2 B 7.82 pIC50 15 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]