ralimetinib [Ligand Id: 7959] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2364626 (LSN-2322600 FREE BASE, LSN2322600 FREE BASE, Ly-2228820, LY-2228820, LY2228820, LY22288220, Ralimetinib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 179-83 [PMID:18039577] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| mitogen-activated protein kinase 11 in Human [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| GtoPdb | Inhibitor potency for EGFR with gatekeeper mutation T790M | - | 5.22 | pIC50 | 6060 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| GtoPdb | Inhibitor potency for WT EGFR | - | 6.74 | pIC50 | 180 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| GtoPdb | Inhibitor potency for EGFRG719C | - | 7.96 | pIC50 | 11 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
