BIRT 377 [Ligand Id: 9720] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL367808
  • integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human [ChEMBL: CHEMBL2096661] [GtoPdb: 24562451] [UniProtKB: P05107P05362P20701]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096661] [GtoPdb: 24562451] [UniProtKB: P05107P05362P20701]
GtoPdb - - 7.59 pKd 25.8 nM Kd J. Immunol. (1999) 163: 5173-7 [PMID:10553036]
ChEMBL Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assay B 7.7 pKd 20 nM Kd J. Med. Chem. (2004) 47: 5356-5366 [PMID:15481974]
ChEMBL Inhibitory concentration against leukocyte function-associated antigen-1 in HSB-2 human lymphoblast and H1HeLa cell adhesion assay F 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1161-1164 [PMID:15686933]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]