BIRT 377 [Ligand Id: 9720] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL367808 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096661] [GtoPdb: 2456, 2451] [UniProtKB: P05107, P05362, P20701] | ||||||||
| GtoPdb | - | - | 7.59 | pKd | 25.8 | nM | Kd | J Immunol (1999) 163: 5173-7 [PMID:10553036] |
| ChEMBL | Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assay | B | 7.7 | pKd | 20 | nM | Kd | J Med Chem (2004) 47: 5356-5366 [PMID:15481974] |
| ChEMBL | Inhibitory concentration against leukocyte function-associated antigen-1 in HSB-2 human lymphoblast and H1HeLa cell adhesion assay | F | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1161-1164 [PMID:15686933] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
