Synonyms: VNRX-5236
Compound class:
Synthetic organic
Comment: Ledaborbactam (VNRX-5236) is a novel broad-spectrum boronic acid β-lactamase inhibitor (BLI). It is a reversible covalent inhibitor of serine β-lactamases (classes A, C, D) [1].
Ledaborbactam etzadroxil (VNRX-7145, PubChem CID 138455030), an orally bioavailable prodrug of ledaborbactam [3], is being developed in combination with ceftibuten for the treatment of infections caused by drug-resistant Enterobacterales. |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(3R)-2-hydroxy-3-(propanoylamino)-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid |
International Nonproprietary Names | |
INN number | INN |
11708 | ledaborbactam |
Synonyms |
VNRX-5236 |
Database Links | |
Specialist databases | |
Antibiotic DB | Ledaborbactam, VNRX-7145 |
Other databases | |
CAS Registry No. | 1842397-36-7 (source: Scifinder) |
ChEMBL Ligand | CHEMBL5093566 |
GtoPdb PubChem SID | 491299864 |
PubChem CID | 138455079 |
Search Google for chemical match using the InChIKey | QAGGLFCWUVSERJ-VIFPVBQESA-N |
Search Google for chemicals with the same backbone | QAGGLFCWUVSERJ |
Search PubMed clinical trials | ledaborbactam |
Search PubMed titles | ledaborbactam |
Search PubMed titles/abstracts | ledaborbactam |
UniChem Compound Search for chemical match using the InChIKey | QAGGLFCWUVSERJ-VIFPVBQESA-N |
UniChem Connectivity Search for chemical match using the InChIKey | QAGGLFCWUVSERJ-VIFPVBQESA-N |