5-oxo-ETE [Ligand Id: 3391] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL18028 (5-Oxo-ETE) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] | ||||||||
| ChEMBL | Inhibition of human platelet 12-lipoxygenase by UV-visible spectrophotometry | B | 4.82 | pIC50 | 15000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| 15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] | ||||||||
| ChEMBL | Inhibition of human reticulocyte 15-lipoxygenase-1 by UV-visible spectrophotometry | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | Inhibition of rabbit reticulocyte 15-LOX by UV-visible spectrophotometry | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] | ||||||||
| ChEMBL | Inhibition of human reticulocyte 15-lipoxygenase-2 by UV-visible spectrophotometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2014) 22: 4293-4297 [PMID:24924423] |
| 5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
| ChEMBL | In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells. | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (1987) 30: 1177-1186 [PMID:3599023] |
| OXE receptor/Oxoeicosanoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628461] [GtoPdb: 271] [UniProtKB: Q8TDS5] | ||||||||
| ChEMBL | Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization | F | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1987-1990 [PMID:21377873] |
| ChEMBL | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay | F | 6.66 | pEC50 | 220 | nM | EC50 | Bioorg Med Chem (2018) 26: 3580-3587 [PMID:29866479] |
| ChEMBL | Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay | F | 7.17 | pEC50 | 67 | nM | EC50 | Medchemcomm (2012) 3: 195-198 |
| ChEMBL | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization | F | 8.15 | pEC50 | 7 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 1857-1860 [PMID:21316960] |
| GtoPdb | - | - | 8.5 | pEC50 | 3.1 | nM | EC50 |
J Biol Chem (1995) 270: 15029-36 [PMID:7797484]; Prostaglandins Other Lipid Mediat (2009) 89: 98-104 [PMID:19450703]; J Pharmacol Exp Ther (2008) 325: 698-707 [PMID:18292294]; J Biol Chem (1998) 273: 32535-41 [PMID:9829988]; J Biol Chem (1992) 267: 19233-41 [PMID:1326548] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
