methylprednisolone [Ligand Id: 7088] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL650 (J3.872E, Medrol, Methylprednisolone, Medrone, NSC-19987, U-67590A)
  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
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  • TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) B 4.75 pKi 17786 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) B 4.57 pIC50 26680 nM IC50 DrugMatrix in vitro pharmacology data
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) B 8.3 pKi 5.03 nM Ki DrugMatrix in vitro pharmacology data
GtoPdb - - 8.3 pKi 5.03 nM Ki National Toxicology Program: Dept of Health and Human Services.. DrugMatrix
ChEMBL DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) B 7.96 pIC50 11 nM IC50 DrugMatrix in vitro pharmacology data
TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62]
GtoPdb Measuring intracellular calcium elevation in HEK293 cells expressing hTRPC5. - 4.92 pEC50 12000 nM EC50 Cell Calcium (2017) 66: 10-18 [PMID:28807145]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]