pentoxifylline [Ligand Id: 7095] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL628 (BL 191, BL-191, C04AD03, Neotren mr, NSC-637086, NSC-758481, Oxpentifylline, Oxypentifylline, Pentoxifylline, Pentoxil, Pentoxiphyllin, Trental, Trental 100, Trental 400) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 5.18 | pIC50 | 6600 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand | B | 5.29 | pKi | 5180 | nM | Ki | J Med Chem (2002) 45: 2131-2138 [PMID:12014951] |
| GtoPdb | - | - | 5.29 | pKi | 5180 | nM | Ki | J Med Chem (2002) 45: 2131-8 [PMID:12014951] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077] |
| phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| ChEMBL | Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay | B | 4.05 | pIC50 | >90000 | nM | IC50 | Eur J Med Chem (2018) 146: 381-394 [PMID:29407965] |
| TNF-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1825] [UniProtKB: P01375] | ||||||||
| ChEMBL | TNF-alpha production in PBMC by ELISA method | F | 4.07 | pIC50 | 85000 | nM | IC50 | J Med Chem (1996) 39: 2-9 [PMID:8568809] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
