BMS-681 [Ligand Id: 9430] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL3577945
  • CCR2/C-C chemokine receptor type 2 in Human [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597]
There should be some charts here, you may need to enable JavaScript!
  • CCR5/C-C chemokine receptor type 5 in Human [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
There should be some charts here, you may need to enable JavaScript!
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
There should be some charts here, you may need to enable JavaScript!
  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR2/C-C chemokine receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597]
ChEMBL Antagonist activity against CCR2 in whole blood (unknown origin) assessed as reduction in CD11b upregulation B 8.33 pIC50 4.7 nM IC50 ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
GtoPdb - - 9.15 pIC50 0.7 nM IC50 ACS Med Chem Lett (2015) 6: 439-44 [PMID:25893046]
ChEMBL Inhibition of [125I]hMCP1 binding to CCR2 in human PBMC incubated for 30 mins at room temperature B 9.15 pIC50 0.7 nM IC50 ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
ChEMBL Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degC B 9.62 pIC50 0.24 nM IC50 ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
ChEMBL Antagonist activity against CCR5 in whole blood (unknown origin) assessed as reduction in CD11b upregulation B 8.37 pIC50 4.3 nM IC50 ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
ChEMBL Inhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrs B 8.62 pIC50 2.4 nM IC50 ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
GtoPdb - - 8.62 pIC50 2.4 nM IC50 ACS Med Chem Lett (2015) 6: 439-44 [PMID:25893046]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in HEK293 cells assessed as reduction in peak tail current at holding potential of 80 mV to +20 mV by whole cell patch clamp assay B 5.74 pIC50 1800 nM IC50 ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Inhibition of muscarinic acetylcholine receptor M1 (unknown origin) B 6.47 pKi 341 nM Ki ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL Inhibition of muscarinic acetylcholine receptor M2 (unknown origin) B 5.4 pKi 4010 nM Ki ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL Inhibition of muscarinic acetylcholine receptor M4 (unknown origin) B 6.06 pKi 865 nM Ki ACS Med. Chem. Lett. (2015) 6: 439-444 [PMID:25893046]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]