ChEMBL ligand: CHEMBL56367 (Aulin, Nimesulida, Nimesulide, NSC-758412, R 805, R-805)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
Dipeptidyl peptidase 3 in Bos mutus [ChEMBL: CHEMBL4105778] [UniProtKB: L8I2E6] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] There should be some charts here, you may need to enable JavaScript!
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] There should be some charts here, you may need to enable JavaScript!
MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] There should be some charts here, you may need to enable JavaScript!
myeloperoxidase/Myeloperoxidase in Human [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] There should be some charts here, you may need to enable JavaScript!
B0AT1 in Rat [GtoPdb: 939] [UniProtKB: Q2A865] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibitory activity was evaluated against human Prostaglandin G/H synthase 1 was determined	B	4.23	pIC50	59000	nM	IC50	Bioorg Med Chem Lett (1998) 8: 529-534 [PMID:9871612]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	4.3	pIC50	50000	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assay	B	4.49	pIC50	32200	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	The inhibitory activity against Prostaglandin G/H synthase 1 measured as TXB2 production after blood coagulation using human Whole blood assay	B	4.66	pIC50	22000	nM	IC50	J Med Chem (2002) 45: 5182-5185 [PMID:12408728]
ChEMBL	In vitro inhibition activity against cyclooxygenase 1 with the compound dissolved in DMSO	B	4.76	pIC50	17400	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3933 [PMID:15993594]
GtoPdb	-	-	4.76	pIC50	17400	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3 [PMID:15993594]
ChEMBL	Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassay	B	4.96	pIC50	10900	nM	IC50	Bioorg Med Chem (2009) 17: 1125-1131 [PMID:19135376]
ChEMBL	Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassay	B	5.42	pIC50	3760	nM	IC50	J Med Chem (2009) 52: 5864-5871 [PMID:19791801]
ChEMBL	Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 production	B	5.42	pIC50	3760	nM	IC50	J Med Chem (2004) 47: 6749-6759 [PMID:15615524]
ChEMBL	Inhibition of COX1	B	5.42	pIC50	3760	nM	IC50	J Med Chem (2011) 54: 2529-2591 [PMID:21413808]
ChEMBL	Inhibition of COX-1 in human whole blood assessed as thromboxane B2 level in serum after 5 mins by enzyme immunoassay	B	5.42	pIC50	3760	nM	IC50	Eur J Med Chem (2014) 74: 12-22 [PMID:24440378]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	5.91	pIC50	1226	nM	IC50	DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2015) 23: 6807-6814 [PMID:26455657]
ChEMBL	Inhibition of ovine COX1 assessed as PGF2alpha level by EIA	B	5.21	pIC50	6200	nM	IC50	Bioorg Med Chem (2011) 19: 2074-2083 [PMID:21349729]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of human COX2 expressed in baculovirus infected sf21 cells assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay	B	4.64	pIC50	23140	nM	IC50	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	5.03	pIC50	9400	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISA	B	5.06	pIC50	8700	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	Inhibition of COX2 in LPS-stimulated human whole blood assessed as TXB2 production by enzyme immunoassay	B	5.46	pIC50	3500	nM	IC50	Bioorg Med Chem (2009) 17: 1125-1131 [PMID:19135376]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader	B	5.77	pIC50	1684	nM	IC50	Eur J Med Chem (2021) 209: 112918-112918 [PMID:33071054]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 5 to 10 mins by fluorometric analysis	B	5.77	pIC50	1680	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)	B	5.84	pIC50	1436	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	The inhibitory activity against cyclooxygenase Prostaglandin G/H synthase 2 (COX-2) measured as PGE-2 production after blood coagulation using human Whole blood assay	B	5.89	pIC50	1300	nM	IC50	J Med Chem (2002) 45: 5182-5185 [PMID:12408728]
ChEMBL	Inhibition of COX2 in LPS-stimulated human whole blood assessed as PGE2 production by enzyme immunoassay	B	6.15	pIC50	700	nM	IC50	J Med Chem (2009) 52: 5864-5871 [PMID:19791801]
ChEMBL	Inhibition of COX2	B	6.15	pIC50	700	nM	IC50	J Med Chem (2011) 54: 2529-2591 [PMID:21413808]
ChEMBL	Inhibition of COX-2 in human whole blood assessed as PGE2 level in plasma after 5 mins by enzyme immunoassay	B	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2014) 74: 12-22 [PMID:24440378]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production	B	6.15	pIC50	700	nM	IC50	J Med Chem (2004) 47: 6749-6759 [PMID:15615524]
GtoPdb	-	-	6.22	pIC50	600	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3 [PMID:15993594]
ChEMBL	In vitro inhibition activity against cyclooxygenase 2 with the compound dissolved in DMSO	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3933 [PMID:15993594]
ChEMBL	Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assay	B	7.64	pIC50	23	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	Inhibitory activity was evaluated against human Prostaglandin G/H synthase 2 was determined	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (1998) 8: 529-534 [PMID:9871612]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method	B	5.72	pIC50	1920	nM	IC50	Bioorg Med Chem (2015) 23: 6807-6814 [PMID:26455657]
ChEMBL	Inhibition of ovine COX2 assessed as PGF2alpha level by EIA	B	6.4	pIC50	400	nM	IC50	Bioorg Med Chem (2011) 19: 2074-2083 [PMID:21349729]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inhibition of aromatase in SK-BR-3 cells by tritiated water release assay	B	4.57	pIC50	27000	nM	IC50	J Med Chem (2007) 50: 1635-1644 [PMID:17315855]
Dipeptidyl peptidase 3 in Bos mutus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105778] [UniProtKB: L8I2E6]
ChEMBL	Mixed type inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrate preincubated for 10 min by Cornish-Bowden plot analysis	B	4.15	pKi	70000	nM	Ki	Med Chem Res (2011) 20: 1294-1297
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	4.93	pKi	11826	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	4.83	pIC50	14884	nM	IC50	DrugMatrix in vitro pharmacology data
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL	Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISA	B	4	pIC50	>100000	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	Inhibition of LTA4 hydrolase in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 0.5 hrs by ELISA	B	4	pIC50	>100000	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL	DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2)	B	4.63	pIC50	23345	nM	IC50	DrugMatrix in vitro pharmacology data
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL	Inhibition of recombinant human myeloperoxidase	B	5.68	pIC50	2100	nM	IC50	J Med Chem (2012) 55: 7208-7218 [PMID:22793255]
B0AT1 in Rat [GtoPdb: 939] [UniProtKB: Q2A865]
GtoPdb	-	-	4.64	pIC50	23000	nM	IC50	Biochem Pharmacol (2014) 89: 422-30 [PMID:24704252]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]