ChEMBL ligand: CHEMBL267473 (Dazoxiben, UK-37248)
CYP11B1/Cytochrome P450 11B1 in Rat [ChEMBL: CHEMBL4970] [GtoPdb: 1359] [UniProtKB: P15393] There should be some charts here, you may need to enable JavaScript!
CYP8A1/Prostaglandin I2 synthase in Human [ChEMBL: CHEMBL4428] [GtoPdb: 1356] [UniProtKB: Q16647] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] CYP5A1/Thromboxane-A synthase in Rat [ChEMBL: CHEMBL4028] [GtoPdb: 1353] [UniProtKB: P49430] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP11B1/Cytochrome P450 11B1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4970] [GtoPdb: 1359] [UniProtKB: P15393]
ChEMBL	Inhibition of rat adrenal 11-beta-hydroxylase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 1643-1650 [PMID:3091830]
ChEMBL	Inhibition of rat adrenal 11-beta-hydroxylase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1985) 28: 1427-1432 [PMID:3930740]
ChEMBL	Inhibition of 11 beta-hydroxylase from rat adrenal gland	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 342-346 [PMID:3081722]
CYP8A1/Prostaglandin I2 synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4428] [GtoPdb: 1356] [UniProtKB: Q16647]
ChEMBL	Inhibition of porcine aorta prostacyclin PGI-2 synthetase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 1643-1650 [PMID:3091830]
ChEMBL	Inhibition of porcine aorta prostacyclin PGI-2 synthase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1985) 28: 1427-1432 [PMID:3930740]
ChEMBL	Inhibition of PGI-2 synthetase from porcine aorta	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 342-346 [PMID:3081722]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg	B	5.6	pIC50	2500	nM	IC50	J Med Chem (1990) 33: 646-652 [PMID:2299629]
ChEMBL	Tested for inhibitory activity against intact human platelet TXA2 formation	F	5.89	pIC50	1290	nM	IC50	J Med Chem (1987) 30: 1588-1595 [PMID:3305945]
ChEMBL	Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.	F	5.89	pIC50	1290	nM	IC50	J Med Chem (1987) 30: 1812-1818 [PMID:3656356]
ChEMBL	Inhibition of Thromboxane-A synthase	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2000) 43: 1841-1851 [PMID:10794700]
ChEMBL	Inhibition of thromboxane synthase P450 TXA2	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2000) 43: 4437-4445 [PMID:11087568]
ChEMBL	Inhibition of platelet microsomal thromboxane A synthetase in humans	B	6.21	pIC50	620	nM	IC50	J Med Chem (1989) 32: 1265-1272 [PMID:2724299]
ChEMBL	Inhibitory activity to inhibit Inophore-induced arachidonic acid metabolism (inhibition of TXB2 formation) in rat	F	6.52	pIC50	300	nM	IC50	J Med Chem (1989) 32: 1842-1860 [PMID:2547071]
ChEMBL	Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets	B	6.6	pIC50	250	nM	IC50	J Med Chem (1987) 30: 185-193 [PMID:2879917]
ChEMBL	Inhibition of platelet microsomal thromboxane A synthetase in rabbits	B	6.97	pIC50	106	nM	IC50	J Med Chem (1989) 32: 1265-1272 [PMID:2724299]
ChEMBL	In vitro inhibitory activity against human microsomal thromboxane synthase.	B	7.15	pIC50	70	nM	IC50	J Med Chem (1995) 38: 1608-1628 [PMID:7752186]
ChEMBL	In vitro inhibition of Thromboxane synthase using [14C]arachidonic acid as radioligand	B	7.55	pIC50	28	nM	IC50	J Med Chem (1991) 34: 1790-1797 [PMID:1829485]
GtoPdb	-	-	8.5	pIC50	-	-	-	Thromb Res (1981) 23: 145-62 [PMID:6795753]
ChEMBL	Inhibition of TXA2 synthetase from human platelets	B	8.52	pIC50	3	nM	IC50	J Med Chem (1986) 29: 342-346 [PMID:3081722]
ChEMBL	Inhibition of thromboxane TXA2 synthetase from human platelets	B	8.52	pIC50	3	nM	IC50	J Med Chem (1986) 29: 1643-1650 [PMID:3091830]
ChEMBL	Inhibitory activity against thromboxane A2 synthetase	B	8.52	pIC50	3	nM	IC50	J Med Chem (1985) 28: 1427-1432 [PMID:3930740]
ChEMBL	In vitro inhibition of thromboxane synthase from human platelets.	B	8.52	pIC50	3	nM	IC50	J Med Chem (1986) 29: 1637-1643 [PMID:3746813]
CYP5A1/Thromboxane-A synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4028] [GtoPdb: 1353] [UniProtKB: P49430]
ChEMBL	Inhibition of thromboxane formation at a concentration of 10e -6 M.	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1987) 30: 1036-1040 [PMID:3585902]
ChEMBL	Compound was tested for inhibitory activity against thromboxane synthetase	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1986) 29: 523-530 [PMID:3959030]
ChEMBL	Compound was tested for the inhibition of thromboxane formation (thromboxane synthetase) in platelets at a concentration of 10e-4 M	F	5.82	pIC50	1500	nM	IC50	J Med Chem (1986) 29: 816-819 [PMID:3517332]
ChEMBL	In vitro inhibition of thromboxane B2 production in rat whole blood.	F	5.92	pIC50	1200	nM	IC50	J Med Chem (1993) 36: 2964-2972 [PMID:8411014]
ChEMBL	Tested for inhibition of thromboxane synthetase from spontaneously hypertensive rats	B	6.82	pIC50	150	nM	IC50	J Med Chem (1987) 30: 2277-2283 [PMID:3681898]
ChEMBL	Inhibition of thromboxane A2 synthetase	B	6.97	pIC50	106	nM	IC50	J Med Chem (1989) 32: 1265-1272 [PMID:2724299]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]