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CYP5, CYP7 and CYP8 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this enzyme family catalyse reactions in the pathways that synthesise or catabolise important lipid mediators, steroids and cholesterol.

Enzymes

1356
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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Cholesterol 7 alpha-hydroxylase (CYP7A1) C Show summary »

CYP7B1 C Show summary »

Prostacyclin synthase (CYP8A1) C Show summary »


Target Id 1356
Nomenclature CYP8A1
Common abbreviation Prostacyclin synthase
Previous and unofficial names PTGIS | PGIS | cytochrome P450, family 8, subfamily A, polypeptide 1 | Prostaglandin I2 (prostacyclin) synthase | prostaglandin I2 (prostacyclin) synthase
Genes PTGIS (Hs), Ptgis (Mm), Ptgis (Rn)
Ensembl ID ENSG00000124212 (Hs), ENSMUSG00000017969 (Mm), ENSRNOG00000008245 (Rn)
UniProtKB AC Q16647 (Hs), O35074 (Mm), Q62969 (Rn)
EC number
5.3.99.4
Inhibitors
compound 7p [PMID: 7861416] pIC50 >6.0 [1]
tranylcypromine [4]
Comment Converts prostaglandin H2 (PGH2) to thromboxane A2 (thromboxane A2) [6].

CYP8B1 C Show summary »

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.