GSK-J4 [Ligand Id: 8979] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3183531
  • lysine demethylase 5B in Human [GtoPdb: 2681] [UniProtKB: Q9UGL1]
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  • lysine demethylase 5C in Human [GtoPdb: 2682] [UniProtKB: P41229]
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  • lysine demethylase 6A in Human [GtoPdb: 2684] [UniProtKB: O15550]
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  • lysine demethylase 6B in Human [GtoPdb: 2685] [UniProtKB: O15054]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
lysine demethylase 5B in Human [GtoPdb: 2681] [UniProtKB: Q9UGL1]
GtoPdb - - 5.01 pIC50 9700 nM IC50 Nature (2014) 514: E1-2 [PMID:25279926]
lysine demethylase 5C in Human [GtoPdb: 2682] [UniProtKB: P41229]
GtoPdb - - 4.82 pIC50 15000 nM IC50 Nature (2014) 514: E1-2 [PMID:25279926]
lysine demethylase 6A in Human [GtoPdb: 2684] [UniProtKB: O15550]
GtoPdb - - 5.18 pIC50 6600 nM IC50 Nature (2014) 514: E1-2 [PMID:25279926]
lysine demethylase 6B in Human [GtoPdb: 2685] [UniProtKB: O15054]
GtoPdb - - 5.07 pIC50 8600 nM IC50 Nature (2014) 514: E1-2 [PMID:25279926]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]