ChEMBL ligand: CHEMBL327745 (SB-213698, TAN-67)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!
MRGPRX2 in Human [GtoPdb: 157] [UniProtKB: Q96LB1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	8.85	pEC50	1.4	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay	F	9.15	pEC50	0.7	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay	F	9.15	pEC50	0.7	nM	EC50	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain membranes	B	8.84	pKi	1.44	nM	Ki	Bioorg Med Chem Lett (2010) 20: 6302-6305 [PMID:20850307]
ChEMBL	inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenates	B	9.64	pKi	0.23	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2967-2972
GtoPdb	Bioassay using mouse vas deferens.	-	8.44	pIC50	3.65	nM	IC50	Drug Des Discov (2001) 17: 325-30 [PMID:11765135]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Displacement of [3H]DADLE from delta opioid receptor in rat cerebellum membrane	B	8.84	pKi	1.44	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Displacement of [3H]DADLE from delta opioid receptor in rat cerebrum membranes	B	8.84	pKi	1.44	nM	Ki	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
ChEMBL	Binding affinity against Kappa opioid receptor using [3H]U-69593 radioligand in mouse brain homogenates	B	6.51	pKi	312	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2967-2972
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebrum membranes	B	6.14	pKi	732.5	nM	Ki	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
ChEMBL	Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig cerebellum	B	6.14	pKi	732.45	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebellum membranes	B	6.14	pKi	732.45	nM	Ki	Bioorg Med Chem Lett (2010) 20: 6302-6305 [PMID:20850307]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain membranes	B	6.55	pKi	284.14	nM	Ki	Bioorg Med Chem Lett (2010) 20: 6302-6305 [PMID:20850307]
ChEMBL	Inhibition of [3H]DAMGO from mouse brain homogenate Mu opioid receptor	B	7.22	pKi	59.6	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2967-2972
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat cerebellum membrane	B	6.55	pKi	284.14	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat cerebrum membranes	B	6.55	pKi	284.1	nM	Ki	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
MRGPRX2 in Human [GtoPdb: 157] [UniProtKB: Q96LB1]
GtoPdb	Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).	-	5.74	pEC50	1820	nM	EC50	J Biomol Screen (2013) 18: 599-609 [PMID:23396314]; Nat Chem Biol (2017) 13: 529-536 [PMID:28288109]; Drug Des Discov (2001) 17: 325-30 [PMID:11765135]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]