ChEMBL ligand: CHEMBL327745 (SB-213698, TAN-67)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!
MRGPRX2 in Human [GtoPdb: 157] [UniProtKB: Q96LB1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	8.85	pEC50	1.4	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay	F	9.15	pEC50	0.7	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay	F	9.15	pEC50	0.7	nM	EC50	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain membranes	B	8.84	pKi	1.44	nM	Ki	Bioorg Med Chem Lett (2010) 20: 6302-6305 [PMID:20850307]
ChEMBL	inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenates	B	9.64	pKi	0.23	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2967-2972
GtoPdb	Bioassay using mouse vas deferens.	-	8.44	pIC50	3.65	nM	IC50	Drug Des Discov (2001) 17: 325-30 [PMID:11765135]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Displacement of [3H]DADLE from delta opioid receptor in rat cerebellum membrane	B	8.84	pKi	1.44	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Displacement of [3H]DADLE from delta opioid receptor in rat cerebrum membranes	B	8.84	pKi	1.44	nM	Ki	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
ChEMBL	Binding affinity against Kappa opioid receptor using [3H]U-69593 radioligand in mouse brain homogenates	B	6.51	pKi	312	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2967-2972
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebrum membranes	B	6.14	pKi	732.5	nM	Ki	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
ChEMBL	Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig cerebellum	B	6.14	pKi	732.45	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebellum membranes	B	6.14	pKi	732.45	nM	Ki	Bioorg Med Chem Lett (2010) 20: 6302-6305 [PMID:20850307]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain membranes	B	6.55	pKi	284.14	nM	Ki	Bioorg Med Chem Lett (2010) 20: 6302-6305 [PMID:20850307]
ChEMBL	Inhibition of [3H]DAMGO from mouse brain homogenate Mu opioid receptor	B	7.22	pKi	59.6	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2967-2972
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat cerebellum membrane	B	6.55	pKi	284.14	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in rat cerebrum membranes	B	6.55	pKi	284.1	nM	Ki	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
MRGPRX2 in Human [GtoPdb: 157] [UniProtKB: Q96LB1]
GtoPdb	Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).	-	5.74	pEC50	1820	nM	EC50	J Biomol Screen (2013) 18: 599-609 [PMID:23396314]; Nat Chem Biol (2017) 13: 529-536 [PMID:28288109]; Drug Des Discov (2001) 17: 325-30 [PMID:11765135]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]