podofilox [Ligand Id: 13598] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL61 (Condyline, Condylox, NSC-24818, Podofilox, Podophyllotoxin, Warticon) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Inhibition of ovine COX1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1787-1791 [PMID:20129783] |
| COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] | ||||||||
| ChEMBL | Inhibition of mouse COX2 | B | 5.4 | pIC50 | >4000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1787-1791 [PMID:20129783] |
| CYP2C19/Cytochrome P450 2C19 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3622] [GtoPdb: 1328] [UniProtKB: P33261] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| CYP2C9/Cytochrome P450 2C9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.4 | pIC50 | 4000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) | B | 6.22 | pIC50 | 600 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] | ||||||||
| ChEMBL | Inhibition of human glucocorticoid receptor | B | 7.85 | pIC50 | 14 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2824-2833 [PMID:19364854] |
| Human papillomavirus regulatory protein E2 in Human papillomavirus type 16 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4656] [UniProtKB: P03120] | ||||||||
| ChEMBL | Binding affinity to HPV16 recombinant E2 protein by surface plasmon resonance method | B | 4.15 | pKd | 70500 | nM | Kd | Bioorg Med Chem (2008) 16: 5815-5825 [PMID:18396405] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method | F | 5.04 | pIC50 | 9200 | nM | IC50 | J Med Chem (2014) 57: 7971-7976 [PMID:25195945] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 asexual blood stages after 3 days by HRP2 detection based ELISA method | F | 5.08 | pIC50 | 8300 | nM | IC50 | J Med Chem (2014) 57: 7971-7976 [PMID:25195945] |
| ChEMBL | Antimalarial activity against chloroquine-resistant erythrocytic stage of Plasmodium falciparum K1 assessed as inhibition of [3H}hypoxanthine incorporation after 24 hrs by liquid scintillation counter | F | 7.92 | pEC50 | 12 | nM | EC50 | Bioorg Med Chem (2011) 19: 2378-2391 [PMID:21411327] |
| Regulatory protein E2 in Human papillomavirus type 11 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5830] [UniProtKB: P04015] | ||||||||
| ChEMBL | Binding affinity to HPV11 recombinant E2 protein by surface plasmon resonance method | B | 4.7 | pKd | 20100 | nM | Kd | Bioorg Med Chem (2008) 16: 5815-5825 [PMID:18396405] |
| Regulatory protein E2 in Human papillomavirus type 1a (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5822] [UniProtKB: P03118] | ||||||||
| ChEMBL | Binding affinity to HPV1a recombinant E2 protein by surface plasmon resonance method | B | 4.62 | pKd | 24100 | nM | Kd | Bioorg Med Chem (2008) 16: 5815-5825 [PMID:18396405] |
| ChEMBL | Binding affinity to HPV1a recombinant E2 protein hinge domain by surface plasmon resonance assay | B | 5.98 | pKd | 1050 | nM | Kd | Bioorg Med Chem (2008) 16: 5815-5825 [PMID:18396405] |
| tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7] | ||||||||
| ChEMBL | Binding affinity to tubulin (unknown origin) assessed as dissociation constant by biolayer interferometry analysis | B | 4.12 | pKd | 76500 | nM | Kd | J Nat Prod (2023) 86: 1844-1854 [PMID:37395092] |
| ChEMBL | Binding affinity to tubulin (unknown origin) assessed as dissociation constant by SPR analysis | B | 4.67 | pKd | 21500 | nM | Kd | Eur J Med Chem (2019) 170: 73-86 [PMID:30878833] |
| ChEMBL | Inhibition of [3H]colchicine binding to beta tubulin | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2006) 49: 5769-5776 [PMID:16970401] |
| ChEMBL | Inhibition of tubulin (unknown origin) polymerization measured for 1 hr by fluorescence assay | B | 5.52 | pIC50 | 3030 | nM | IC50 | Bioorg Med Chem (2014) 22: 2714-2723 [PMID:24721832] |
| ChEMBL | Inhibition of tubulin polymerization | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2006) 49: 2357-2360 [PMID:16570932] |
| ChEMBL | In vitro inhibition of mammalian tubulin polymerization by 50% | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1998) 41: 1956-1961 [PMID:9599244] |
| ChEMBL | Inhibition of tubulin polymerization in human K562 cells | B | 6.46 | pIC50 | 350 | nM | IC50 | Eur J Med Chem (2010) 45: 3354-3364 [PMID:20546980] |
| ChEMBL | Inhibition of tubulin polymerization (unknown origin) preincubated for 10 mins followed by GTP addition measured after 20 mins by Coomassie blue staining based SDS-PAGE analysis | B | 6.59 | pIC50 | 260 | nM | IC50 | Eur J Med Chem (2017) 141: 460-472 [PMID:29055869] |
| Tubulin in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111464] [UniProtKB: Q6B856, Q862F3] | ||||||||
| ChEMBL | Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentration | F | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2003) 46: 1670-1682 [PMID:12699385] |
| Tubulin alpha chain in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3658] [UniProtKB: P02550] | ||||||||
| ChEMBL | Inhibition of tubulin polymerization. (ITP) | B | 6.34 | pIC50 | 460 | nM | IC50 | J Med Chem (2001) 44: 3932-3936 [PMID:11689079] |
| Tubulin beta chain in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3394] [UniProtKB: Q6B856] | ||||||||
| ChEMBL | Inhibition of tubulin polymerization | F | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1993) 36: 1146-1156 [PMID:8387598] |
| ChEMBL | Inhibition of tubulin polymerization | F | 6.34 | pIC50 | 460 | nM | IC50 | J Med Chem (1994) 37: 1126-1135 [PMID:8164254] |
| ChEMBL | Inhibition of bovine tubulin polymerization | F | 6.34 | pIC50 | 460 | nM | IC50 | J Med Chem (1997) 40: 2266-2275 [PMID:9216846] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
