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ChEMBL ligand: CHEMBL255682 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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presenilin 1/presenilin 2/Gamma-secretase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094135] [GtoPdb: 2402, 2403] [UniProtKB: P49768, P49810, Q8WW43, Q92542, Q96BI3, Q9NZ42] | ||||||||
ChEMBL | Displacement of [3H]L685458 from gamma-secretase in human THP1 cells | B | 4 | pIC50 | >100000 | nM | IC50 | J Biol Chem (2007) 282: 36829-36836 [PMID:17932033] |
ChEMBL | Inhibition of gamma secretase (unknown origin) mediated Notch signaling by cell based luciferase reporter gene assay | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2016) 59: 7719-7737 [PMID:27045975] |
ChEMBL | Inhibition of gamma secretase in human primary neuronal cells assessed as reduction in amyloid beta 40 | B | 6.94 | pIC50 | 115 | nM | IC50 | J Med Chem (2016) 59: 7719-7737 [PMID:27045975] |
ChEMBL | Displacement of [3H]IN973 from gamma-secretase in human THP1 cells | B | 8.2 | pIC50 | 6.3 | nM | IC50 | J Biol Chem (2007) 282: 36829-36836 [PMID:17932033] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]