ChEMBL ligand: CHEMBL255682
presenilin 1/presenilin 2/Gamma-secretase in Human [ChEMBL: CHEMBL2094135] [GtoPdb: 2402, 2403] [UniProtKB: P49768, P49810, Q8WW43, Q92542, Q96BI3, Q9NZ42] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
presenilin 1/presenilin 2/Gamma-secretase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094135] [GtoPdb: 2402, 2403] [UniProtKB: P49768, P49810, Q8WW43, Q92542, Q96BI3, Q9NZ42]
ChEMBL	Displacement of [3H]L685458 from gamma-secretase in human THP1 cells	B	4	pIC50	>100000	nM	IC50	J Biol Chem (2007) 282: 36829-36836 [PMID:17932033]
ChEMBL	Inhibition of gamma secretase (unknown origin) mediated Notch signaling by cell based luciferase reporter gene assay	B	6.3	pIC50	500	nM	IC50	J Med Chem (2016) 59: 7719-7737 [PMID:27045975]
ChEMBL	Inhibition of gamma secretase in human primary neuronal cells assessed as reduction in amyloid beta 40	B	6.94	pIC50	115	nM	IC50	J Med Chem (2016) 59: 7719-7737 [PMID:27045975]
ChEMBL	Displacement of [3H]IN973 from gamma-secretase in human THP1 cells	B	8.2	pIC50	6.3	nM	IC50	J Biol Chem (2007) 282: 36829-36836 [PMID:17932033]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]