glipizide   Click here for help

GtoPdb Ligand ID: 6821

Synonyms: CP-28720 | Glucotrol® | K-4024
Approved drug
glipizide is an approved drug (FDA (1984))
Compound class: Synthetic organic
Comment: A sulfonylurea family drug inhibiting sulfonylurea receptor 1 (ABCC8)/Kir6.2 (KCNJ11).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 138.53
Molecular weight 445.18
XLogP 2.26
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES Cc1ncc(nc1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Isomeric SMILES Cc1ncc(nc1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
InChI InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
InChI Key ZJJXGWJIGJFDTL-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1984))
IUPAC Name Click here for help
N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-5-methylpyrazine-2-carboxamide
International Nonproprietary Names Click here for help
INN number INN
3090 glipizide
Synonyms Click here for help
CP-28720 | Glucotrol® | K-4024
Database Links Click here for help
CAS Registry No. 29094-61-9
ChEMBL Ligand CHEMBL1073
DrugBank Ligand DB01067
DrugCentral Ligand 1301
GtoPdb PubChem SID 178103427
PubChem CID 3478
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Wikipedia Glipizide