ofloxacin [Ligand Id: 10918] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4 (DL-8280, Exocin, Floxin, Floxin otic, HOE 280, HOE-280, J01MA01, NSC-727071, NSC-758178, Ocuflox, Ofloxacin, Tarivid, Tarivid 400, Tarivid i.v., Visiren) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] | ||||||||
| GtoPdb | DNA-supercoiling assay | - | 5.46 | pIC50 | 3500 | nM | IC50 | Antimicrob Agents Chemother (2001) 45: 1994-2000 [PMID:11408214] |
| ChEMBL | Inhibition of Escherichia coli DNA gyrase GyrA/GyrB | B | 5.82 | pIC50 | 1500 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 2909-2914 [PMID:18426901] |
| DNA gyrase subunit A/DNA gyrase subunit B in Escherichia coli [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] | ||||||||
| GtoPdb | DNA-supercoiling assay | - | 5.46 | pIC50 | 3500 | nM | IC50 | Antimicrob Agents Chemother (2001) 45: 1994-2000 [PMID:11408214] |
| DNA gyrase subunit A/DNA gyrase subunit B in Mycobacterium tuberculosis (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430898] [UniProtKB: P9WG45, P9WG47] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB | B | 4.55 | pIC50 | 28000 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 2909-2914 [PMID:18426901] |
| GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14] | ||||||||
| ChEMBL | Inhibition of [3H]muscimol binding to GABA A receptor with compound alone at 10 e-4 M | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1993) 36: 1356-1363 [PMID:8388467] |
| ChEMBL | Inhibition of [3H]muscimol binding to GABA A receptor 4-biphenylacetic acid at 10 e-4 M | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (1993) 36: 1356-1363 [PMID:8388467] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| TAS2R9 in Human [GtoPdb: 665] [UniProtKB: Q9NYW1] | ||||||||
| GtoPdb | - | - | 3.7 | pEC50 | 200000 | nM | EC50 | PLoS One (2008) 3: e3974 [PMID:19092995] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
