ChEMBL ligand: CHEMBL666 (Dihydroxyphosphinecarboxylic Acid Oxide, Foscarnet, J05AD01)
DNA polymerase in Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) [ChEMBL: CHEMBL4859] [UniProtKB: P09252] There should be some charts here, you may need to enable JavaScript!
DNA polymerase alpha subunit in Human [ChEMBL: CHEMBL1828] [UniProtKB: P09884] There should be some charts here, you may need to enable JavaScript!
DNA polymerase delta subunit 1 in Human [ChEMBL: CHEMBL2735] [UniProtKB: P28340] There should be some charts here, you may need to enable JavaScript!
Human herpesvirus 5 DNA polymerase in Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [ChEMBL: CHEMBL3414] [UniProtKB: P08546] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DNA polymerase in Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4859] [UniProtKB: P09252]
ChEMBL	Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C; [nd = not determined]	B	6.55	pIC50	<280	nM	IC50	J. Med. Chem. (2005) 48: 5794-5804 [PMID:16134946]
DNA polymerase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1828] [UniProtKB: P09884]
ChEMBL	Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO	B	4.7	pIC50	>20000	nM	IC50	J. Med. Chem. (2005) 48: 5794-5804 [PMID:16134946]
DNA polymerase delta subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2735] [UniProtKB: P28340]
ChEMBL	Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C with the compound dissolved in DMSO	B	4.7	pIC50	>20000	nM	IC50	J. Med. Chem. (2005) 48: 5794-5804 [PMID:16134946]
Human herpesvirus 5 DNA polymerase in Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3414] [UniProtKB: P08546]
ChEMBL	Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C	B	5.6	pIC50	2500	nM	IC50	J. Med. Chem. (2005) 48: 5794-5804 [PMID:16134946]
ChEMBL	Inhibition of HCMV DNA polymerase by scintillation proximity assay	B	5.6	pIC50	2500	nM	IC50	Bioorg. Med. Chem. Lett. (2007) 17: 3349-3353 [PMID:17434304]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in absence of Mg2+ ions by band shift assay	B	4.86	pKd	13900	nM	Kd	J. Biol. Chem. (2007) 282: 3337-3346 [PMID:17145704]
ChEMBL	Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in presence of Mg2+ ions by band shift assay	B	6.4	pKd	400	nM	Kd	J. Biol. Chem. (2007) 282: 3337-3346 [PMID:17145704]
ChEMBL	Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]dGTP as a radioligand	B	4.25	pIC50	56000	nM	IC50	J. Med. Chem. (2004) 47: 3418-3426 [PMID:15189038]
ChEMBL	Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer	B	4.62	pIC50	24000	nM	IC50	J. Med. Chem. (2004) 47: 3418-3426 [PMID:15189038]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase E89T mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity assay	B	5.28	pIC50	5200	nM	IC50	J. Med. Chem. (2014) 57: 7435-7449 [PMID:25144111]
ChEMBL	Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA/DNAM duplex primed substrate by scintillation proximity assay	B	5.3	pIC50	>5000	nM	IC50	J. Biol. Chem. (2007) 282: 8005-8010 [PMID:17172472]
ChEMBL	Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay	B	5.3	pIC50	>5000	nM	IC50	J. Biol. Chem. (2007) 282: 8005-8010 [PMID:17172472]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase K65R mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity assay	B	5.55	pIC50	2800	nM	IC50	J. Med. Chem. (2014) 57: 7435-7449 [PMID:25144111]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity assay	B	5.6	pIC50	2500	nM	IC50	J. Med. Chem. (2014) 57: 7435-7449 [PMID:25144111]
ChEMBL	Inhibition of wild type HIV1 reverse transcriptase M184V mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity assay	B	6.1	pIC50	800	nM	IC50	J. Med. Chem. (2014) 57: 7435-7449 [PMID:25144111]
ChEMBL	Inhibition of HIV1 reverse transcriptase p66/p51 polymerase using PPT57 DNA/Cy5-labeled PPT24 as template/primer preincubated for 10 mins followed by dNTP addition measured after 5 mins by bromophenol blue staining based phosphor imaging analysis	B	6.1	pIC50	800	nM	IC50	Bioorg Med Chem (2018) 26: 1713-1726 [PMID:29478802]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]