AM2201 [Ligand Id: 9705] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3526578 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor in Human [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| GtoPdb | - | - | 7.42 | pEC50 | 38 | nM | EC50 | ACS Chem Neurosci (2015) 6: 1445-58 [PMID:25921407] |
| CB1 receptor/Cannabinoid CB1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] | ||||||||
| ChEMBL | Displacement of [3H]CP-55,940 from CB1 receptor in B6SJL mouse brain membrane after 90 mins by liquid scintillation spectrophotometric analysis | B | 9.4 | pKi | 0.4 | nM | Ki | Drug Metab Dispos (2012) 40: 2174-2184 [PMID:22904561] |
| CB1 receptor in Rat [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| GtoPdb | Binding affinity vs. rat forebrain membranes. | - | 9 | pKi | 1 | nM | Ki | WO2001028557. Cannabimimetic indole derivatives (2001) |
| CB2 receptor in Human [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| GtoPdb | - | - | 7.23 | pEC50 | 58.8 | nM | EC50 | ACS Chem Neurosci (2015) 6: 1445-58 [PMID:25921407] |
| CB2 receptor in Mouse [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
| GtoPdb | Binding affinity vs. mouse spleen membranes. | - | 8.59 | pKi | 2.6 | nM | Ki | WO2001028557. Cannabimimetic indole derivatives (2001) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
