lorazepam

Ligand id: 5884

Name: lorazepam

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 61.69
Molecular weight 320.01
XLogP 3.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1977))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
International Nonproprietary Names
INN number INN
2809 lorazepam
Synonyms
Ativan® | Orfidal®
Comments
Lorazepam is used for the short-term management of severe anxiety. where it is thought to have a high affinity for GABA receptors. In March of 2016 it has also been reported as a GPR68 surrogate allosteric ligand [1].
Database Links
CAS Registry No. 846-49-1 (source: SciFinder)
ChEMBL Ligand CHEMBL580
DrugBank Ligand DB00186
GtoPdb PubChem SID 178102508
PubChem CID 3958
Search Google for chemical match using the InChIKey DIWRORZWFLOCLC-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DIWRORZWFLOCLC
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Search UniChem for chemical match using the InChIKey DIWRORZWFLOCLC-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DIWRORZWFLOCLC
Wikipedia Lorazepam

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Lorazepam
Cat. No. 3087