Synonyms: Example 124 [US20190023662] [2] | OPB171775
Compound class:
Synthetic organic
Comment: OPB-171775 is a molecular glue [3]. Structurally it is a PDE3A inhibitor derivative. In gastrointestinal stromal tumour cells it promotes formation of a ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). PDE3A/SLFN12 complex formation activates the pro-apoptotic ribonuclease activity of SLFN12, which results in a cytotoxic antitumour effect [1]. This molecular mechanism is proposed as an alternative to tyrosine kinase inhibitor (TKI)-based cancer therapies, particularly for TKI-resistant tumours.
|
|
Classification ![]() |
|
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
(4R)-3-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one |
Synonyms ![]() |
|
Example 124 [US20190023662] [2] | OPB171775 |
Database Links ![]() |
|
CAS Registry No. | 2131210-15-4 (source: PubChem) |
GtoPdb PubChem SID | 504705462 |
PubChem CID | 137378218 |
Search Google for chemical match using the InChIKey | GGUTYKLJESECBW-MRVPVSSYSA-N |
Search Google for chemicals with the same backbone | GGUTYKLJESECBW |
UniChem Compound Search for chemical match using the InChIKey | GGUTYKLJESECBW-MRVPVSSYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | GGUTYKLJESECBW-MRVPVSSYSA-N |