cyclizine   Click here for help

GtoPdb Ligand ID: 7151

Synonyms: Marezine®
Approved drug
cyclizine is an approved drug (FDA (date unknown))
Compound class: Synthetic organic
Comment: Cyclizine is an antihistamine drug used primarily for its anti-nausea and antiemetic actions.
Cyclizine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 6.48
Molecular weight 266.18
XLogP 2.99
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Isomeric SMILES CN1CCN(CC1)C(c1ccccc1)c1ccccc1
InChI InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
InChI Key UVKZSORBKUEBAZ-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (date unknown))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name Click here for help
1-(diphenylmethyl)-4-methylpiperazine
International Nonproprietary Names Click here for help
INN number INN
176 cyclizine
Synonyms Click here for help
Marezine®
Database Links Click here for help
CAS Registry No. 82-92-8
ChEMBL Ligand CHEMBL648
DrugBank Ligand DB01176
DrugCentral Ligand 749
GtoPdb PubChem SID 178103726
PubChem CID 6726
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Wikipedia Cyclizine