cyclizine   

GtoPdb Ligand ID: 7151

Synonyms: Marezine®
cyclizine is an approved drug (FDA (date unknown))
Compound class: Synthetic organic
Comment: Cyclizine is an antihistamine drug used primarily for its anti-nausea and antiemetic actions.
Cyclizine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 6.48
Molecular weight 266.18
XLogP 2.99
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Isomeric SMILES CN1CCN(CC1)C(c1ccccc1)c1ccccc1
InChI InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
InChI Key UVKZSORBKUEBAZ-UHFFFAOYSA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (date unknown))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
1-(diphenylmethyl)-4-methylpiperazine
International Nonproprietary Names
INN number INN
176 cyclizine
Synonyms
Marezine®
Database Links
CAS Registry No. 82-92-8
ChEMBL Ligand CHEMBL648
DrugBank Ligand DB01176
DrugCentral Ligand 749
GtoPdb PubChem SID 178103726
PubChem CID 6726
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Wikipedia Cyclizine