Synonyms: Marezine®
cyclizine is an approved drug (FDA (date unknown))
Compound class:
Synthetic organic
Comment: Cyclizine is an antihistamine drug used primarily for its anti-nausea and antiemetic actions.
Cyclizine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: cyclizine |
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No information available. |
Summary of Clinical Use ![]() |
Used to treat the symptoms of motion sickness, and nausea experienced post-operatively, or associated with radiotherapy. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Cyclizine blocks the action of endogenous histamine at the histamine H1 receptor in the vomiting center of the medullary brain.. |
External links ![]() |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) |