ChEMBL ligand: CHEMBL8946 (Eticlopride)
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb	-	-	9.2	pKi	-	-	-	Eur J Pharmacol (1994) 266: 79-85 [PMID:7907989]; J Pharmacol Exp Ther (1994) 268: 495-502 [PMID:8301592]
ChEMBL	Displacement of [3H]N-methylspiperone from human D2R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assay	B	9.59	pKi	0.26	nM	Ki	J Med Chem (2016) 59: 10676-10691 [PMID:27933960]
ChEMBL	Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes measured after 60 mins by MicroBeta scintillation counting method	B	9.93	pKi	0.12	nM	Ki	J Med Chem (2021) 64: 15313-15333 [PMID:34636551]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysis	B	10.07	pKi	0.09	nM	Ki	J Med Chem (2014) 57: 4962-4968 [PMID:24848155]
ChEMBL	Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 10 mins by BRET assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2016) 59: 10676-10691 [PMID:27933960]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissue	B	9.77	pKd	0.17	nM	Kd	J Med Chem (1990) 33: 171-178 [PMID:2136916]
ChEMBL	Affinity constant of compound was evaluated in rat striatum tissue preparation.	B	9.77	pKd	0.17	nM	Kd	J Med Chem (1988) 31: 1039-1043 [PMID:2966245]
ChEMBL	Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride	B	9	pKi	0.99	nM	Ki	J Med Chem (1991) 34: 1612-1624 [PMID:1827843]
ChEMBL	Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence of sodium chloride	B	9.72	pKi	0.19	nM	Ki	J Med Chem (1991) 34: 1612-1624 [PMID:1827843]
ChEMBL	Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2	B	9.92	pKi	0.12	nM	Ki	J Med Chem (1990) 33: 1155-1163 [PMID:1969484]
ChEMBL	Compound was evaluated for the inhibition constant against dopamine receptor D2 in rat	B	10.05	pKi	0.09	nM	Ki	J Med Chem (1993) 36: 221-228 [PMID:8093734]
ChEMBL	In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.	B	9.04	pIC50	0.92	nM	IC50	J Med Chem (1990) 33: 1155-1163 [PMID:1969484]
ChEMBL	Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitro	B	9.04	pIC50	0.92	nM	IC50	J Med Chem (1991) 34: 948-955 [PMID:1672158]
ChEMBL	Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2	B	9.04	pIC50	0.92	nM	IC50	J Med Chem (1993) 36: 3417-3423 [PMID:7901417]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb	-	-	8.8	pKi	-	-	-	Eur J Pharmacol (1994) 266: 79-85 [PMID:7907989]; J Pharmacol Exp Ther (1994) 268: 495-502 [PMID:8301592]
ChEMBL	Compound was measured for its ability to compete with [125I]NCQ298 binding to the human Dopamine receptor D3 transfected in CHO cells	B	9.8	pKi	0.16	nM	Ki	J Med Chem (2003) 46: 4377-4392 [PMID:14521403]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysis	B	9.87	pKi	0.13	nM	Ki	J Med Chem (2014) 57: 4962-4968 [PMID:24848155]
ChEMBL	Displacement of [3H]N-methylspiperone from human D3R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assay	B	9.96	pKi	0.11	nM	Ki	J Med Chem (2016) 59: 10676-10691 [PMID:27933960]
ChEMBL	Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes measured after 60 mins by MicroBeta scintillation counting method	B	9.97	pKi	0.11	nM	Ki	J Med Chem (2021) 64: 15313-15333 [PMID:34636551]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
GtoPdb	-	-	7	pKi	-	-	-	Life Sci (1995) 57: PL275-83 [PMID:7475902]
ChEMBL	Displacement of [3H]N-methylspiperone from human D4R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assay	B	7.15	pKi	70.4	nM	Ki	J Med Chem (2016) 59: 10676-10691 [PMID:27933960]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]