hydroxyurea [Ligand Id: 6822] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL467 (Droxia, Hydrea, Hydroxycarbamide, Hydroxyurea, NSC-32065, Siklos, SQ 1089, SQ-1089) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human CA2 | B | 4.55 | pKi | 28000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4316-4320 [PMID:16759856] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human CA9 | B | 4.64 | pKi | 23000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4316-4320 [PMID:16759856] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human CA5a | B | 4.51 | pKi | 31000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4316-4320 [PMID:16759856] |
| ribonucleotide reductase catalytic subunit M1 in Human [GtoPdb: 2630] [UniProtKB: P23921] | ||||||||
| GtoPdb | Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme | - | 3.83 | pIC50 | 148000 | nM | IC50 | Biochem Pharmacol (2005) 69: 627-34 [PMID:15670581] |
| ribonucleotide reductase regulatory subunit M2 in Human [GtoPdb: 2631] [UniProtKB: P31350] | ||||||||
| GtoPdb | Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme | - | 3.83 | pIC50 | 148000 | nM | IC50 | Biochem Pharmacol (2005) 69: 627-34 [PMID:15670581] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
