Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL4785363 (Ccs 1477, Ccs1477, CCS-1477, CCS1477, Inobrodib) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
CREB binding protein in Human [GtoPdb: 2734] [UniProtKB: Q92793] | ||||||||
GtoPdb | Binding affinity for recombinant hCBP bromodomain determined by isothermal titration calorimetry (ITC). | - | 7.85 | pKd | 14 | nM | Kd | J Med Chem (2022) 65: 785-810 [PMID:34962793] |
GtoPdb | Binding affinity for hCBP bromodomain determined by surface plasmon resonance (SPR). | - | 8.77 | pKd | 1.7 | nM | Kd | Cancer Discov (2021) 11: 1118-1137 [PMID:33431496] |
E1A binding protein p300 in Human [GtoPdb: 2735] [UniProtKB: Q09472] | ||||||||
GtoPdb | Binding affinity for human p300 bromodomain determined by surface plasmon resonance (SPR) | - | 8.77 | pKd | 1.7 | nM | Kd | Cancer Discov (2021) 11: 1118-1137 [PMID:33431496] |
GtoPdb | Inhibition of histone binding determined in a cell-based BRET assay. | - | 7.72 | pIC50 | 19 | nM | IC50 | Cancer Discov (2021) 11: 1118-1137 [PMID:33431496] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]