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Target not currently curated in GtoImmuPdb
Target id: 2728
Nomenclature: bromodomain containing 9
Abbreviated Name: BRD9
Family: Bromodomain kinase (BRDK) family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 597 | 5p15.33 | BRD9 | bromodomain containing 9 | |
Mouse | - | 596 | 13 C1 | Brd9 | bromodomain containing 9 | |
Rat | - | 589 | 1p11 | Brd9 | bromodomain containing 9 |
Database Links ![]() |
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Alphafold | Q9H8M2 (Hs), Q3UQU0 (Mm) |
CATH/Gene3D | 1.20.920.10 |
ChEMBL Target | CHEMBL3108640 (Hs), CHEMBL3822347 (Mm) |
Ensembl Gene | ENSG00000028310 (Hs), ENSMUSG00000057649 (Mm), ENSRNOG00000015676 (Rn) |
Entrez Gene | 65980 (Hs), 105246 (Mm), 308067 (Rn) |
Human Protein Atlas | ENSG00000028310 (Hs) |
KEGG Gene | hsa:65980 (Hs), mmu:105246 (Mm), rno:308067 (Rn) |
Pharos | Q9H8M2 (Hs) |
RefSeq Nucleotide | NM_001009877 (Hs), NM_001024508 (Mm), NM_001107453 (Rn) |
RefSeq Protein | NP_001009877 (Hs), NP_001019679 (Mm), NP_001100923 (Rn) |
SynPHARM |
83214 (in complex with BI-9564) 82102 (in complex with I-BRD9) 82362 (in complex with LP99) |
UniProtKB | Q9H8M2 (Hs), Q3UQU0 (Mm) |
Wikipedia | BRD9 (Hs) |
Selected 3D Structures ![]() |
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Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP et al.. (2018) Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife, 7: e41305. DOI: 10.7554/eLife.41305 [PMID:30431433]
2. Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, Monteiro OP, Bennett JM, Baronio R, Müller S et al.. (2015) LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl, 54 (21): 6217-21. [PMID:25864491]
3. Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, Yapp C, Philpott M, Martin SJ, Felletar I et al.. (2014) [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. J Med Chem, 57 (2): 462-76. [PMID:24313754]
4. Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D et al.. (2016) Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem, 59 (10): 4462-75. [PMID:26914985]
5. Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA et al.. (2017) Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl, 56 (21): 5738-5743. [PMID:28418626]
6. SCC. BI-9564 A chemical probe for BRD9 and BRD7. Accessed on 11/12/2015. Modified on 11/12/2015. thesgc.org, http://www.thesgc.org/chemical-probes/BI-9564
7. SGC. TP-472 A BRD9/7 Probe. Accessed on 05/04/2017. Modified on 04/08/2023. Structural Genomics Consortium., https://www.thesgc.org/chemical-probes/TP-472
8. Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, Chung CW, Dittmann A, Drewes G, Drewry DH et al.. (2016) Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J Med Chem, 59 (4): 1425-39. [PMID:25856009]
Bromodomain kinase (BRDK) family: bromodomain containing 9. Last modified on 12/11/2019. Accessed on 13/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2728.