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Bromodomain kinase (BRDK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Bromodomain (BRD)-containing kinases initiate acetylation-dependent assembly of transcriptional regulator complexes by binding to (or 'reading') acetyl-lysine marks on histone tails. The regulator complexes thus formed, control expression of sets of proteins which alter the cellular phenotype in specific ways. (BRD)-containing proteins are exciting targets for the development of novel small molecule therapeutics in the areas of cancer, inflammation and viral infection [1].

Enzymes

BRD1 (bromodomain containing 1) Show summary » More detailed page

BRD2 (bromodomain containing 2) Show summary » More detailed page

BRD3 (bromodomain containing 3) Show summary » More detailed page

BRD4 (bromodomain containing 4) Show summary » More detailed page

BRD7 (bromodomain containing 7) Show summary » More detailed page

BRD8 (bromodomain containing 8) Show summary » More detailed page

BRD9 (bromodomain containing 9) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Bromodomain kinase (BRDK) family. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=558.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.