ChEMBL ligand: CHEMBL25202 (Am80, AM-80, Amnoid, INNO-507, NSC-608000, OP-01, RR-110, Sy-1425, SY-1425, Tamibarotene, TM-411, TOS-80T)
Flavin reductase in Human [ChEMBL: CHEMBL5019] [UniProtKB: P30043] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Flavin reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5019] [UniProtKB: P30043]
ChEMBL	Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry	B	5.86	pKd	1380.38	nM	Kd	J Med Chem (2022) 65: 2548-2557 [PMID:34957824]
ChEMBL	Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry	B	5.86	pKd	1380	nM	Kd	J Med Chem (2022) 65: 2548-2557 [PMID:34957824]
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL	Agonistic activity towards retinoic acid receptor-alpha	F	8.19	pKi	6.5	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
GtoPdb	-	-	6.9	pIC50	-	-	-	J Med Chem (1988) 31: 2182-92 [PMID:3184125]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761]; Curr Pharm Des (2000) 6: 25-58 [PMID:10637371]
ChEMBL	Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)	B	7.11	pIC50	78	nM	IC50	J Med Chem (2000) 43: 409-419 [PMID:10669568]
ChEMBL	Agonist activity at RARalpha	F	7.35	pEC50	45	nM	EC50	J Med Chem (2010) 53: 6779-6810 [PMID:20925433]
GtoPdb	-	-	7.35	pEC50	45	nM	EC50	J Med Chem (2010) 53: 6779-810 [PMID:20925433]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL	Agonistic activity towards retinoic acid receptor-beta	F	7.52	pKi	30	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
ChEMBL	Agonist activity at RARbeta	F	6.63	pEC50	235	nM	EC50	J Med Chem (2010) 53: 6779-6810 [PMID:20925433]
GtoPdb	-	-	6.63	pEC50	235	nM	EC50	J Med Chem (2010) 53: 6779-810 [PMID:20925433]
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL	Agonist activity at RARgamma	F	6.23	pEC50	591	nM	EC50	J Med Chem (2010) 53: 6779-6810 [PMID:20925433]
GtoPdb	-	-	6.23	pEC50	591	nM	EC50	J Med Chem (2010) 53: 6779-810 [PMID:20925433]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]