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ChEMBL ligand: CHEMBL25202 (AM80, AM-80, NSC-608000, Tamibarotene) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
ChEMBL | Agonistic activity towards retinoic acid receptor-alpha | F | 8.19 | pKi | 6.5 | nM | Ki | J. Med. Chem. (1997) 40: 4222-4234 [PMID:9435893] |
GtoPdb | - | - | 6.9 | pIC50 | - | - | - |
J Med Chem (1988) 31: 2182-92 [PMID:3184125]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761]; Curr Pharm Des (2000) 6: 25-58 [PMID:10637371] |
ChEMBL | Binding affinity for Retinoic Acid Receptor alpha (RAR alpha) | B | 7.11 | pIC50 | 78 | nM | IC50 | J. Med. Chem. (2000) 43: 409-419 [PMID:10669568] |
ChEMBL | Agonist activity at RARalpha | F | 7.35 | pEC50 | 45 | nM | EC50 | J. Med. Chem. (2010) 53: 6779-6810 [PMID:20925433] |
GtoPdb | - | - | 7.35 | pEC50 | 45 | nM | EC50 | J Med Chem (2010) 53: 6779-810 [PMID:20925433] |
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
ChEMBL | Agonistic activity towards retinoic acid receptor-beta | F | 7.52 | pKi | 30 | nM | Ki | J. Med. Chem. (1997) 40: 4222-4234 [PMID:9435893] |
ChEMBL | Agonist activity at RARbeta | F | 6.63 | pEC50 | 235 | nM | EC50 | J. Med. Chem. (2010) 53: 6779-6810 [PMID:20925433] |
GtoPdb | - | - | 6.63 | pEC50 | 235 | nM | EC50 | J Med Chem (2010) 53: 6779-810 [PMID:20925433] |
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
ChEMBL | Agonist activity at RARgamma | F | 6.23 | pEC50 | 591 | nM | EC50 | J. Med. Chem. (2010) 53: 6779-6810 [PMID:20925433] |
GtoPdb | - | - | 6.23 | pEC50 | 591 | nM | EC50 | J Med Chem (2010) 53: 6779-810 [PMID:20925433] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]