CYP26A1 | CYP24, CYP26 and CYP27 families | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 1366

Nomenclature: CYP26A1

Family: CYP24, CYP26 and CYP27 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP26A1 cytochrome P450 family 26 subfamily A member 1
Mouse - - Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1
Rat - - Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1
Previous and Unofficial Names
retinoic acid 4-hydroxylase | cytochrome P450, 26, retinoic acid | retinoic acid hydroxylase | cytochrome P450, family 26, subfamily A, polypeptide 1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | cytochrome P450
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number: 1.14.-.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5 [PMID: 21838328] Hs Inhibition 9.5 pIC50 1
pIC50 9.5 (IC50 3.5x10-10 M) [1]
Description: Measuring retinoic acid metabolism in a cell-free microsomal assay.


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1. Gomaa MS, Bridgens CE, Veal GJ, Redfern CP, Brancale A, Armstrong JL, Simons C. (2011) Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26). J. Med. Chem., 54 (19): 6803-11. [PMID:21838328]

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