CX516 [Ligand Id: 4165] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL136800 (Ampalex, BDP 12, BDP-12, Cx516, CX 516, CX-516)
  • HPGD/15-hydroxyprostaglandin dehydrogenase [NAD+] in Human [ChEMBL: CHEMBL1293255] [GtoPdb: 1384] [UniProtKB: P15428]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HPGD/15-hydroxyprostaglandin dehydrogenase [NAD+] in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293255] [GtoPdb: 1384] [UniProtKB: P15428]
ChEMBL Inhibition of 15-PGDH (unknown origin) using NAD as substrate measured for 3.5 mins B 7 pIC50 100 nM IC50 J Med Chem (2022) 65: 15327-15343 [PMID:36322935]
GluA3/GluA4/Glutamate receptor AMPA 3/4 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885582] [GtoPdb: 446, 447] [UniProtKB: P19492, P19493]
ChEMBL Inhibition of GluR3/4 rat in hippocampal neuron B 4.02 pEC50 95000 nM EC50 J Med Chem (2010) 53: 7271-7279 [PMID:20839777]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]