butaprost [Ligand Id: 3379] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL271896 (BAY Q 4218, BAY-Q-4218, BAYQ-4218, Butaprost, TR-4979)
  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
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  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
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  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
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  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Binding affinity to EP1 receptor (unknown origin) B 5 pKi >10000 nM Ki J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Binding affinity to EP2 receptor (unknown origin) by competitive binding assay B 5.62 pKi 2400 nM Ki J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL Binding affinity at human prostaglandin EP2 receptor B 6.96 pKi 110 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 6572-6575 [PMID:17931866]
ChEMBL Displacement of [3H]PGE2 from human EP2 receptor B 6.96 pKi 110 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 821-824 [PMID:18039575]
ChEMBL Agonist activity at EP2 receptor (unknown origin) by functional assay B 7.48 pEC50 33 nM EC50 J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Binding affinity to EP3 receptor (unknown origin) B 5 pKi >10000 nM Ki J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Binding affinity at human prostaglandin EP4 receptor B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 6572-6575 [PMID:17931866]
ChEMBL Displacement of [3H]PGE4 from human EP4 receptor B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 821-824 [PMID:18039575]
ChEMBL Binding affinity to EP4 receptor (unknown origin) B 5 pKi >10000 nM Ki J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Binding affinity to prostanoid IP receptor (unknown origin) B 5 pKi >10000 nM Ki J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL Agonist activity at prostanoid IP receptor (unknown origin) by functional assay B 7.43 pIC50 37 nM IC50 J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]