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ChEMBL ligand: CHEMBL271896 (BAY Q 4218, BAY-Q-4218, BAYQ-4218, Butaprost, TR-4979) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
ChEMBL | Binding affinity to EP1 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689] |
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
ChEMBL | Binding affinity to EP2 receptor (unknown origin) by competitive binding assay | B | 5.62 | pKi | 2400 | nM | Ki | J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689] |
ChEMBL | Binding affinity at human prostaglandin EP2 receptor | B | 6.96 | pKi | 110 | nM | Ki | Bioorg. Med. Chem. Lett. (2007) 17: 6572-6575 [PMID:17931866] |
ChEMBL | Displacement of [3H]PGE2 from human EP2 receptor | B | 6.96 | pKi | 110 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 821-824 [PMID:18039575] |
ChEMBL | Agonist activity at EP2 receptor (unknown origin) by functional assay | B | 7.48 | pEC50 | 33 | nM | EC50 | J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689] |
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
ChEMBL | Binding affinity to EP3 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689] |
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
ChEMBL | Binding affinity at human prostaglandin EP4 receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg. Med. Chem. Lett. (2007) 17: 6572-6575 [PMID:17931866] |
ChEMBL | Displacement of [3H]PGE4 from human EP4 receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 821-824 [PMID:18039575] |
ChEMBL | Binding affinity to EP4 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689] |
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
ChEMBL | Binding affinity to prostanoid IP receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689] |
ChEMBL | Agonist activity at prostanoid IP receptor (unknown origin) by functional assay | B | 7.43 | pIC50 | 37 | nM | IC50 | J. Med. Chem. (2014) 57: 4454-4465 [PMID:24279689] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]