ChEMBL ligand: CHEMBL4519023
SOS Ras/Rac guanine nucleotide exchange factor 1/Son of sevenless homolog 1 in Human [ChEMBL: CHEMBL2079846] [GtoPdb: 3096] [UniProtKB: Q07889] There should be some charts here, you may need to enable JavaScript!
KRAS/SOS Ras/Rac guanine nucleotide exchange factor 1/SOS1-KRAS in Human [ChEMBL: CHEMBL5465393] [GtoPdb: 2824, 3096] [UniProtKB: P01116, Q07889] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
SOS Ras/Rac guanine nucleotide exchange factor 1/Son of sevenless homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079846] [GtoPdb: 3096] [UniProtKB: Q07889]
ChEMBL	Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysis	B	6.33	pKd	470	nM	Kd	Eur J Med Chem (2024) 268: 116282-116282 [PMID:38430853]
ChEMBL	Binding affinity to SOS1 (unknown origin)	B	8.01	pKd	9.7	nM	Kd	J Med Chem (2024) 67: 2487-2511 [PMID:38316747]
ChEMBL	Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysis	B	8.01	pKd	9.7	nM	Kd	J Med Chem (2024) 67: 1563-1579 [PMID:38206836]
ChEMBL	Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysis	B	8.52	pKd	3	nM	Kd	J Med Chem (2021) 64: 6569-6580 [PMID:33719426]
GtoPdb	Binding affinity determined by SPR	-	8.01	pKi	9.7	nM	Ki	Cancer Discov (2021) 11: 142-157 [PMID:32816843]
ChEMBL	Inhibition of SOS1-mediated proliferation of human NCI-H520 cells assessed as proliferation incubated for 5 to 14 days by AlamarBlue based 3D proliferation assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2021) 64: 6569-6580 [PMID:33719426]
ChEMBL	Inhibition of human recombinant SOS1	B	7.06	pIC50	86.59	nM	IC50	J Med Chem (2024) 67: 7130-7145 [PMID:38630077]
ChEMBL	Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and measured after 30 mins by HTRF assay	B	7.14	pIC50	71.8	nM	IC50	ACS Med Chem Lett (2023) 14: 183-190 [PMID:36793426]
ChEMBL	Inhibition of SOS1 (unknown origin) mediated KRAS activation by HTRF method	B	7.38	pIC50	41.4	nM	IC50	Bioorg Med Chem Lett (2024) 107: 129780-129780 [PMID:38714262]
ChEMBL	Inhibition of SOS1-mediated proliferation of human DLD-1 cells assessed as proliferation incubated for 5 to 14 days by AlamarBlue based 3D proliferation assay	B	7.44	pIC50	36	nM	IC50	J Med Chem (2021) 64: 6569-6580 [PMID:33719426]
ChEMBL	Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysis	B	7.77	pIC50	17	nM	IC50	Eur J Med Chem (2023) 261: 115828-115828 [PMID:37778239]
ChEMBL	Inhibition of GST-tagged SOS1 (564 to 1049 amino acids) (unknown origin) assessed as reduction SOS1/6xHis-Tev-tagged K-Ras G12D mutant (1 to 169 residues) interaction incubated for 30 mins by AlphaLISA method	B	8.3	pIC50	5	nM	IC50	WO-2018115380-A1. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors (2018)
ChEMBL	Inhibition of SOS1 (unknown origin)	B	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2023) 261: 115828-115828 [PMID:37778239]
ChEMBL	Inhibition of SOS1 (unknown origin) by SPR assay	B	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2023) 259: 115698-115698 [PMID:37542991]
KRAS/SOS Ras/Rac guanine nucleotide exchange factor 1/SOS1-KRAS in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL5465393] [GtoPdb: 2824, 3096] [UniProtKB: P01116, Q07889]
GtoPdb	Binding affinity determined by SPR	-	8.01	pKi	9.7	nM	Ki	Cancer Discov (2021) 11: 142-157 [PMID:32816843]
ChEMBL	Inhibition of SOS1/KRAS G13D mutant protein-protein interaction in human DLD-1 cells assessed as ERK1/2 phosphorylation measured after 70 mins by AlphaScreen assay	B	7.62	pIC50	24	nM	IC50	J Med Chem (2021) 64: 6569-6580 [PMID:33719426]
ChEMBL	Inhibition of human SOS1/GST-tagged KRAS G12C mutant (unknown origin) protein-protein interaction expressed in Escherichia coli BL21(DE3) measured after 30 mins by NMR analysis	B	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2023) 261: 115828-115828 [PMID:37778239]
ChEMBL	Inhibition of human recombinant SOS1 (residue 564-1049)/KRAS G12C mutant protein-protein interaction at incubated for 25 degC for 60 mins by homogeneous time-resolved fluorescence (HTRF) method	B	8.08	pIC50	8.3	nM	IC50	J Med Chem (2022) 65: 15856-15877 [PMID:36384290]
ChEMBL	Inhibition of N-terminal GST-tagged SOS1 (564 to 1049 residues)/N-terminal his6-tagged KRAS (unknown origin) protein-protein interaction incubated for 30 mins by microplate reader analysis	B	8.3	pIC50	5	nM	IC50	J Med Chem (2024) 67: 1563-1579 [PMID:38206836]
ChEMBL	Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction	B	8.3	pIC50	5	nM	IC50	RSC Med Chem (2024) 15: 1392-1403 [PMID:38665844]
ChEMBL	Inhibition of SOS1/KRAS (unknown origin) protein-protein interaction by alpha screen assay	B	8.3	pIC50	5	nM	IC50	Eur J Med Chem (2024) 268: 116282-116282 [PMID:38430853]
ChEMBL	Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysis	B	8.34	pIC50	4.6	nM	IC50	ACS Med Chem Lett (2024) 15: 958-964 [PMID:38894918]
ChEMBL	Inhibition of human SOS1/GST-tagged KRAS G12C mutant (unknown origin) protein-protein interaction expressed in Escherichia coli BL21(DE3) incubated for 30 mins by NMR analysis	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2023) 88: 129265-129265 [PMID:37011767]
ChEMBL	Inhibition of SOS1/KRAS (unknown origin) protein-protein interaction by alpha screen assay	B	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2023) 259: 115698-115698 [PMID:37542991]
ChEMBL	Inhibition of SOS1/KRAS G12D mutant (unknown origin) protein-protein interaction using GDP nucleotide as substrate measured after 30 mins by Alphascreen assay	B	8.4	pIC50	4	nM	IC50	J Med Chem (2021) 64: 6569-6580 [PMID:33719426]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]