nitrofural [Ligand Id: 12366] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL869 (Actin-n, Furacilin, Furacin, Furacine, Furazone, Nitrofural, Nitrofurazone, NSC-1602, NSC-2100)
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  • Snake venom metalloproteinase Bap1 in Bothrops asper [ChEMBL: CHEMBL2079851] [UniProtKB: P83512]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NAD(+) hydrolase SARM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523350] [UniProtKB: Q6SZW1]
ChEMBL Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 15 mins B 4.05 pIC50 90000 nM IC50 Bioorg Med Chem (2020) 28: 115644-115644 [PMID:32828421]
Snake venom metalloproteinase Bap1 in Bothrops asper (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079851] [UniProtKB: P83512]
ChEMBL Inhibition of snake venom BaP1 using Abz-Ala-Gly-Leu-Ala-Nba as substrate incubated for 30 mins prior to substrate addition by fluorescence spectrophotometry B 4.06 pIC50 88100 nM IC50 ACS Med Chem Lett (2012) 3: 540-543 [PMID:24900507]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]