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ChEMBL ligand: CHEMBL287423 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
GtoPdb | - | - | 7.74 | pKi | 18 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
ChEMBL | Binding affinity against human cathepsin D | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
Cathepsin D in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4106] [UniProtKB: P80209] | ||||||||
ChEMBL | Inhibitory activity against bovine Cathepsin D | B | 6.79 | pIC50 | 164 | nM | IC50 | J Med Chem (1992) 35: 2-14 [PMID:1732531] |
cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091] | ||||||||
GtoPdb | - | - | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
ChEMBL | Binding affinity against human cathepsin E | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
pepsinogen A5/Pepsin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3295] [GtoPdb: 2390] [UniProtKB: P0DJD9] | ||||||||
ChEMBL | Binding affinity against human pepsin | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
GtoPdb | - | - | 7.96 | pKi | 11 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
progastricsin/Pepsinogen C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2136] [GtoPdb: 2391] [UniProtKB: P20142] | ||||||||
ChEMBL | Binding affinity against human gastricsin | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
GtoPdb | - | - | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] | ||||||||
ChEMBL | The concentration producing 50% inhibition of renin activity in monkey plasma was determined by radioimmunoassay. | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1992) 35: 2-14 [PMID:1732531] |
ChEMBL | Inhibitory activity against monkey renin | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]