ChEMBL ligand: CHEMBL287423
cathepsin D/Cathepsin D in Human [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] Cathepsin D in Bovine [ChEMBL: CHEMBL4106] [UniProtKB: P80209] There should be some charts here, you may need to enable JavaScript!
cathepsin E/Cathepsin E in Human [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091] There should be some charts here, you may need to enable JavaScript!
pepsinogen A5/Pepsin A in Human [ChEMBL: CHEMBL3295] [GtoPdb: 2390] [UniProtKB: P0DJD9] There should be some charts here, you may need to enable JavaScript!
progastricsin/Pepsinogen C in Human [ChEMBL: CHEMBL2136] [GtoPdb: 2391] [UniProtKB: P20142] There should be some charts here, you may need to enable JavaScript!
renin/Renin in Human [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339]
GtoPdb	-	-	7.74	pKi	18	nM	Ki	J Med Chem (1993) 36: 2614-20 [PMID:8410973]
ChEMBL	Binding affinity against human cathepsin D	B	7.74	pKi	18	nM	Ki	J Med Chem (1993) 36: 2614-2620 [PMID:8410973]
Cathepsin D in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4106] [UniProtKB: P80209]
ChEMBL	Inhibitory activity against bovine Cathepsin D	B	6.79	pIC50	164	nM	IC50	J Med Chem (1992) 35: 2-14 [PMID:1732531]
cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091]
GtoPdb	-	-	9.3	pKi	0.5	nM	Ki	J Med Chem (1993) 36: 2614-20 [PMID:8410973]
ChEMBL	Binding affinity against human cathepsin E	B	9.3	pKi	0.5	nM	Ki	J Med Chem (1993) 36: 2614-2620 [PMID:8410973]
pepsinogen A5/Pepsin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3295] [GtoPdb: 2390] [UniProtKB: P0DJD9]
ChEMBL	Binding affinity against human pepsin	B	7.96	pKi	11	nM	Ki	J Med Chem (1993) 36: 2614-2620 [PMID:8410973]
GtoPdb	-	-	7.96	pKi	11	nM	Ki	J Med Chem (1993) 36: 2614-20 [PMID:8410973]
progastricsin/Pepsinogen C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2136] [GtoPdb: 2391] [UniProtKB: P20142]
ChEMBL	Binding affinity against human gastricsin	B	9.05	pKi	0.9	nM	Ki	J Med Chem (1993) 36: 2614-2620 [PMID:8410973]
GtoPdb	-	-	9.05	pKi	0.9	nM	Ki	J Med Chem (1993) 36: 2614-20 [PMID:8410973]
renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797]
ChEMBL	The concentration producing 50% inhibition of renin activity in monkey plasma was determined by radioimmunoassay.	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (1992) 35: 2-14 [PMID:1732531]
ChEMBL	Inhibitory activity against monkey renin	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (1993) 36: 2614-2620 [PMID:8410973]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]