compound 3 [PMID: 8410973] [Ligand Id: 8634] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL287423
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339]
GtoPdb - - 7.74 pKi 18 nM Ki J Med Chem (1993) 36: 2614-20 [PMID:8410973]
ChEMBL Binding affinity against human cathepsin D B 7.74 pKi 18 nM Ki J. Med. Chem. (1993) 36: 2614-2620 [PMID:8410973]
Cathepsin D in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4106] [UniProtKB: P80209]
ChEMBL Inhibitory activity against bovine Cathepsin D B 6.79 pIC50 164 nM IC50 J. Med. Chem. (1992) 35: 2-14 [PMID:1732531]
cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091]
GtoPdb - - 9.3 pKi 0.5 nM Ki J Med Chem (1993) 36: 2614-20 [PMID:8410973]
ChEMBL Binding affinity against human cathepsin E B 9.3 pKi 0.5 nM Ki J. Med. Chem. (1993) 36: 2614-2620 [PMID:8410973]
pepsinogen A5/Pepsin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3295] [GtoPdb: 2390] [UniProtKB: P0DJD9]
ChEMBL Binding affinity against human pepsin B 7.96 pKi 11 nM Ki J. Med. Chem. (1993) 36: 2614-2620 [PMID:8410973]
GtoPdb - - 7.96 pKi 11 nM Ki J Med Chem (1993) 36: 2614-20 [PMID:8410973]
progastricsin/Pepsinogen C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2136] [GtoPdb: 2391] [UniProtKB: P20142]
ChEMBL Binding affinity against human gastricsin B 9.05 pKi 0.9 nM Ki J. Med. Chem. (1993) 36: 2614-2620 [PMID:8410973]
GtoPdb - - 9.05 pKi 0.9 nM Ki J Med Chem (1993) 36: 2614-20 [PMID:8410973]
renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797]
ChEMBL The concentration producing 50% inhibition of renin activity in monkey plasma was determined by radioimmunoassay. B 8.92 pIC50 1.2 nM IC50 J. Med. Chem. (1992) 35: 2-14 [PMID:1732531]
ChEMBL Inhibitory activity against monkey renin B 9.4 pIC50 0.4 nM IC50 J. Med. Chem. (1993) 36: 2614-2620 [PMID:8410973]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]